Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Reductively metabolized glutamine is a major cellular carbon source for fatty acid synthesis during hypoxia or when mitochondrial respiration is impaired. Yet, a mechanistic understanding of what determines reductive metabolism is missing. Here we identify several cellular conditions where the α-ket...

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Bibliographic Details
Main Authors: Fendt, Sarah-Maria (Contributor), Bell, Eric L. (Contributor), Mayers, Jared R. (Contributor), Vokes, Natalie I. (Contributor), Stephanopoulos, Gregory (Contributor), Keibler, Mark Andrew (Contributor), Wasylenko, Thomas Michael (Contributor), Guarente, Leonard Pershing (Contributor), Vander Heiden, Matthew G. (Contributor), Olenchock, Benjamin (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-11-07T19:00:02Z.
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