The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Proliferating mammalian cells use glutamine as a source of nitrogen and as a key anaplerotic source to provide metabolites to the tricarboxylic acid cycle (TCA) for biosynthesis. Recently, mammalian target of rapamycin complex 1 (mTORC1) activation has been correlated with increased nutrient uptake...

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Main Authors: Csibi, Alfred (Author), Fendt, Sarah-Maria (Contributor), Li, Chenggang (Author), Poulogiannis, George (Author), Choo, Andrew Y (Author), Chapski, Douglas J (Author), Jeong, Seung Min (Author), Dempsey, Jamie M. (Author), Parkhitko, Andrey (Author), Morrison, Tasha (Author), Henske, Elizabeth P. (Author), Haigis, Marcia C. (Author), Cantley, Lewis C. (Author), Stephanopoulos, Gregory (Contributor), Yu, Jane (Author), Blenis, John (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-11-07T19:16:59Z.
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