Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer outcomes remains controversial. To explore how metformin might directly affect can...

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Bibliographic Details
Main Authors: Fendt, Sarah-Maria (Contributor), Bell, Eric L. (Contributor), Keibler, Mark Andrew (Contributor), Davidson, Shawn Michael (Contributor), Wirth, Gregory J. (Author), Fiske, Brian Prescott (Contributor), Mayers, Jared R. (Contributor), Schwab, Matthias (Author), Bellinger, Gary (Author), Csibi, Alfred (Author), Patnaik, Akash (Author), Blouin, Marie Jose (Author), Cantley, Lewis C. (Author), Guarente, Leonard Pershing (Contributor), Blenis, John (Author), Pollak, Michael N. (Author), Olumi, Aria F. (Author), Vander Heiden, Matthew G. (Contributor), Stephanopoulos, Gregory (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2014-11-07T19:50:25Z.
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