TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR influences life span will identify mechanisms of fundamental importance in aging and TOR functions. Here we show that when TO...

Full description

Bibliographic Details
Main Authors: Robida-Stubbs, Stacey (Author), Glover-Cutter, Kira (Author), Lamming, Dudley W (Author), Mizunuma, Masaki (Author), Narasimhan, Sri Devi (Author), Neumann-Haefelin, Elke (Author), Sabatini, David M (Author), Blackwell, T. Keith (Author), Lamming, Dudley W. (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-11-12T13:50:59Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items