p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer

Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little progress in developing effective therapies. v-raf murine sarcoma viral oncogene...

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Main Authors: McFadden, David Glenn (Contributor), Vernon, Amanda (Contributor), Santiago, Philip M. (Contributor), Martinez-McFaline, Raul (Contributor), Crowley, Denise M. (Contributor), McMahon, Martin (Author), Sadow, Peter M. (Author), Bhutkar, Arjun (Author), Jacks, Tyler E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Bhutkar, Arjun (AJ) (Contributor), Jacks, Tyler E. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2014-11-12T13:56:33Z.
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