The Polycomb Group Protein L3mbtl2 Assembles an Atypical PRC1-Family Complex that Is Essential in Pluripotent Stem Cells and Early Development

The Polycomb Group Protein L3mbtl2 Assembles an Atypical PRC1-Family Complex that Is Essential in Pluripotent Stem Cells and Early Development

L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has not been defined. Here we show that disruption of L3mbtl2 results in embryonic lethality with failure of gastrulation. This correlates with compromised proliferation and abnormal differ...

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Main Authors: Qin, Jinzhong (Author), Whyte, Warren A (Author), Anderssen, Endre (Author), Apostolou, Effie (Author), Chen, Hsu-Hsin (Author), Akbarian, Schahram (Author), Bronson, Roderick T. (Author), Hochedlinger, Konrad (Author), Ramaswamy, Sridhar (Author), Young, Richard A (Author), Hock, Hanno (Author), Young, Richard A. (Contributor), Whyte, Warren Anthony (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Whyte, Warren A. (Contributor)
Format: Article
Language:English
Published: Elsevier B.V., 2014-11-14T20:05:46Z.
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