Effect of Small-Molecule-Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody
Small-molecule ligands specific for tumor-associated surface receptors have wide applications in cancer diagnosis and therapy. Achieving high-affinity binding to the desired target is important for improving detection limits and for increasing therapeutic efficacy. However, the affinity required for...
Main Authors: | Rhoden, John J. (Contributor), Ruiz-Yi, Benjamin (Contributor), Wittrup, Karl Dane (Contributor), Frangioni, John V. (Author), Orcutt, Kelly Davis (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Association for Cancer Research,
2014-11-20T14:50:02Z.
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Subjects: | |
Online Access: | Get fulltext |
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