Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls

Decades ago, two nonoverlapping crypt stem cell populations were proposed: Leblond's Crypt Base Columnar (CBC) cell and Potten's +4 cell. The identification of CBC markers including Lgr5 has confirmed Leblond's predictions that CBC cells are anatomically distinct, long-lived stem cell...

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Bibliographic Details
Main Authors: Barker, Nick (Author), van Oudenaarden, Alexander (Author), Clevers, Hans (Author), van Oudenaarden, Alexander (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
Format: Article
Language:English
Published: Elsevier, 2014-12-01T17:17:48Z.
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