Structure-based programming of lymph-node targeting in molecular vaccines

Structure-based programming of lymph-node targeting in molecular vaccines

In cancer patients, visual identification of sentinel lymph nodes (LNs) is achieved by the injection of dyes that bind avidly to endogenous albumin, targeting these compounds to LNs, where they are efficiently filtered by resident phagocytes1, 2. Here we translate this 'albumin hitchhiking'...

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Main Authors: Liu, Haipeng (Author), Moynihan, Kelly Dare (Contributor), Zheng, Yiran (Contributor), Szeto, Gregory Lee (Contributor), Li, Adrienne Victoria (Contributor), Huang, Bonnie (Contributor), Van Egeren, Debra S. (Contributor), Irvine, Darrell J. (Contributor), Lui, Haipeng (Contributor), Park, Clara, S.M. Massachusetts Institute of Technology (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Park, Clara (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2014-12-01T19:35:13Z.
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