Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state

The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation. We found that Msi genes are rarely mutated but frequently overexpressed in human cancers and...

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Main Authors: Katz, Yarden (Contributor), Li, Feifei (Author), Lambert, Nicole J. (Author), Tam, Wai-Leong (Author), Airoldi, Edoardo M. (Author), Lengner, Christopher J. (Author), Yu, Zhengquan (Author), Jaenisch, Rudolf (Contributor), Sokol, Ethan Samuel (Contributor), Cheng, Albert W. (Contributor), Gupta, Piyush (Contributor), Burge, Christopher B (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Whitehead Institute for Biomedical Research (Contributor), Burge, Christopher B. (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd., 2014-12-18T16:48:54Z.
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