Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney

Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney

Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA damage; the alkyladenine DNA glycosylase (Aag/Mpg...

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Main Authors: Daneshmand, Ali (Author), Mazumder, Aprotim (Contributor), Allocca, Mariacarmela (Author), Calvo, Jennifer A. (Contributor), Abolhassani, Nona (Contributor), Jhun, Iny (Contributor), Muthupalani, Sureshkumar (Contributor), Ayata, Cenk (Author), Ebrahimkhani, Mohammad Reza (Contributor), Samson, Leona D (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Samson, Leona D. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2015-04-08T19:57:59Z.
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