Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Bacterial type II CRISPR-Cas9 systems have been widely adapted for RNA-guided genome editing and transcription regulation in eukaryotic cells, yet their in vivo target specificity is poorly understood. Here we mapped genome-wide binding sites of a catalytically inactive Cas9 (dCas9) from Streptococc...

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Main Authors: Wu, Xuebing (Contributor), Cheng, Albert W. (Author), Chen, Sidi (Contributor), Jaenisch, Rudolf (Contributor), Zhang, Feng (Contributor), Chiu, Anthony Chun-yin (Contributor), Sharp, Phillip A. (Contributor), Scott, David Arthur (Contributor), Hsu, Patrick (Contributor), Trevino, Alexandro E. (Contributor), Kriz, Andrea J. (Contributor), Dadon, Daniel Benjamin (Contributor), Konermann, Silvana M (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Konermann, Silvana M. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-10T18:06:29Z.
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