TALEN-mediated editing of the mouse Y chromosome

TALEN-mediated editing of the mouse Y chromosome

The functional study of Y chromosome genes has been hindered by a lack of mouse models with specific Y chromosome mutations. We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and i...

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Main Authors: Wang, Haoyi (Contributor), Hu, Yueh-Chiang (Contributor), Markoulaki, Styliani (Contributor), Welstead, G Grant (Author), Shivalila, Chikdu Shakti (Contributor), Pyntikova, Tatyana (Contributor), Dadon, Daniel Benjamin (Contributor), Voytas, Daniel F. (Author), Bogdanove, Adam J. (Author), Jaenisch, Rudolf (Contributor), Welstead, G. Grant (Contributor), Cheng, Albert Wu (Author), Page, David C (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Cheng, Albert W. (Contributor), Page, David C. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-13T16:08:11Z.
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