A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

Genes encoding components of the PI3K-AKT-mTOR signaling axis are frequently mutated in cancer, but few mutations have been characterized in MTOR, the gene encoding the mTOR kinase. Using publicly available tumor genome sequencing data, we generated a comprehensive catalog of mTOR pathway mutations...

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Bibliographic Details
Main Authors: Grabiner, Brian C. (Author), Nardi, Valentina (Author), Birsoy, Kivanc (Author), Possemato, Richard (Author), Shen, Kuang (Author), Sinha, Sumi (Author), Jordan, Alexander (Author), Beck, Andrew H. (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2015-04-23T17:15:49Z.
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