Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling

Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling

In mouse embryos at mid-gestation, primordial germ cells (PGCs) undergo licensing to become gametogenesis-competent cells (GCCs), gaining the capacity for meiotic initiation and sexual differentiation. GCCs then initiate either oogenesis or spermatogenesis in response to gonadal cues. Germ cell lice...

Full description

Bibliographic Details
Main Authors: Hu, Yueh-Chiang (Contributor), Nicholls, Peter K. (Contributor), Soh, Ying Qi Shirleen (Contributor), Daniele, Joseph R. (Contributor), Junker, Jan Philipp (Author), van Oudenaarden, Alexander (Contributor), Page, David C (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Whitehead Institute for Biomedical Research (Contributor), Page, David C. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2015-04-23T17:28:17Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items