The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA or RagB bound to RagC or RagD) in order to promote the translocation of mT...

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Main Authors: Chantranupong, Lynne (Contributor), Orozco, Jose M (Author), Scaria, Sonia M (Author), Bar-Peled, Liron (Author), Spooner, Eric (Author), Isasa, Marta (Author), Gygi, Steven P. (Author), Sabatini, David M (Author), Wolfson, Rachel Laura (Contributor), Saxton, Robert Andrew (Contributor), Scaria, Sonia M. (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-04-23T18:00:27Z.
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