Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, Ragulator-, and vacuolar adenosine triphosphatase-dependent fashion, the translocation of mTORC1 to the lysosomal surface...

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Main Authors: Plovanich, M. E. (Author), Straub, C. (Author), Sabatini, B. L. (Author), Tsun, Zhi-Yang (Contributor), Wang, Shuyu (Contributor), Wolfson, Rachel Laura (Contributor), Shen, Kuang (Contributor), Wyant, Gregory Andrew (Contributor), Yuan, Elizabeth D. (Contributor), Jones, Tony D. (Contributor), Chantranupong, Lynne (Contributor), Comb, William C. (Contributor), Wang, Tim (Contributor), Bar-Peled, Liron (Contributor), Zoncu, Roberto (Contributor), Kim, Choah (Contributor), Park, Jiwon (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-04-23T18:19:44Z.
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