Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells

Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells

Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we perform...

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Main Authors: Chen, Walter W. (Contributor), Mihaylova, Maria M. (Author), Snitkin, Harriet (Author), Stasinski, Iwona (Author), Yucel, Burcu (Author), Bayraktar, Erol C. (Author), Carette, Jan E. (Author), Clish, Clary (Author), Brummelkamp, Thijn R. (Author), Sabatini, David M (Author), Birsoy, Kivanc (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-04-23T18:24:23Z.
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