The TSC-mTOR pathway regulates macrophage polarization

The TSC-mTOR pathway regulates macrophage polarization

Macrophages are able to polarize to proinflammatory M1 or alternative M2 states with distinct phenotypes and physiological functions. How metabolic status regulates macrophage polarization remains not well understood, and here we examine the role of mTOR (mechanistic target of rapamycin), a central...

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Main Authors: Byles, Vanessa (Author), Covarrubias, Anthony J. (Author), Ben-Sahra, Issam (Author), Lamming, Dudley W. (Contributor), Manning, Brendan D. (Author), Horng, Tiffany (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-23T19:03:52Z.
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