Rapamycin Doses Sufficient to Extend Lifespan Do Not Compromise Muscle Mitochondrial Content or Endurance

Rapamycin Doses Sufficient to Extend Lifespan Do Not Compromise Muscle Mitochondrial Content or Endurance

Rapamycin extends lifespan in mice, but can have a number of undesirable effects that may ultimately limit its utility in humans. The canonical target of rapamycin, and the one thought to account for its effects on lifespan, is the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). We ha...

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Bibliographic Details
Main Authors: Ye, Lan (Author), Widlund, Anne L. (Author), Sims, Carrie A. (Author), Lamming, Dudley W. (Contributor), Guan, Yuxia (Author), Davis, James G. (Author), Harrison, David E. (Author), Vang, Ole (Author), Baur, Joseph A. (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Impact Journals, 2015-04-23T19:19:14Z.
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