Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH-Mutant Gliomas

Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH-Mutant Gliomas

Purpose: Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity in IDH-mutant gliomas. Methods: We prospectively implanted tumor specimens from 20 consecutive IDH1-mutant glioma resections...

Full description

Bibliographic Details
Main Authors: Wakimoto, H. (Author), Tanaka, S. (Author), Curry, W. T. (Author), Loebel, F. (Author), Zhao, D. (Author), Tateishi, K. (Author), Chen, J. (Author), Klofas, L. K. (Author), Lelic, N. (Author), Kim, J. C. (Author), Dias-Santagata, D. (Author), Ellisen, L. W. (Author), Borger, D. R. (Author), Fendt, Sarah-Maria (Author), Batchelor, Tracy T. (Author), Iafrate, A. John (Author), Cahill, D. P. (Author), Chi, A. S. (Author), Vander Heiden, Matthew G. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2015-04-28T19:35:30Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items