Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Tumour oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacological inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymatic cofactors tha...

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Main Authors: Kwiatkowski, Nicholas P. (Author), Zhang, Tinghu (Author), Rahl, Peter B. (Author), Abraham, Brian J. (Author), Reddy, Jessica (Contributor), Ficarro, Scott B. (Author), Dastur, Anahita (Author), Amzallag, Arnaud (Author), Ramaswamy, Sridhar (Author), Tesar, Bethany (Author), Jenkins, Catherine E. (Author), Hannett, Nancy M. (Author), McMillin, Douglas (Author), Sanda, Takaomi (Author), Sim, Taebo (Author), Kim, Nam Doo (Author), Look, A. Thomas (Author), Mitsiades, Constantine S. (Author), Weng, Andrew P. (Author), Brown, Jennifer R. (Author), Benes, Cyril H. (Author), Marto, Jarrod A. (Author), Young, Richard A. (Contributor), Gray, Nathanael S. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-04-30T12:51:59Z.
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