Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines

Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines

B-cells are promising candidate autologous antigen-presenting cells (APCs) to prime antigen-specific T-cells both in vitro and in vivo. However to date, a significant barrier to utilizing B-cells as APCs is their low capacity for non-specific antigen uptake compared to "professional" APCs...

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Main Authors: Lee Szeto, Gregory (Author), Alejandro, Brian (Contributor), Park, Clara (Contributor), Frew, Kirubel (Author), Brefo, Mavis S. (Contributor), Mao, Shirley (Contributor), Heimann, Megan (Contributor), Van Egeren, Debra S. (Contributor), Sharei, Armon Reza (Contributor), Worku, Hermoon A. (Contributor), Langer, Robert S (Author), Irvine, Darrell J (Author), Jensen, Klavs F (Author), Szeto, Gregory (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Szeto, Gregory Lee (Contributor), Irvine, Darrell J. (Contributor), Langer, Robert (Contributor), Jensen, Klavs F. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2015-05-28T16:57:23Z.
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