Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees

Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees

The adaptive immune response to vaccination or infection can lead to the production of specific antibodies to neutralize the pathogen or recruit innate immune effector cells for help. The non-neutralizing role of antibodies in stimulating effector cell responses may have been a key mechanism of the...

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Main Authors: Choi, Ickwon (Author), Chung, Amy W. (Author), Suscovich, Todd J. (Author), Rerks-Ngarm, Supachai (Author), Pitisuttithum, Punnee (Author), Nitayaphan, Sorachai (Author), Kaewkungwal, Jaranit (Author), O'Connell, Robert J. (Author), Francis, Donald (Author), Robb, Merlin L. (Author), Michael, Nelson L. (Author), Kim, Jerome H. (Author), Alter, Galit (Contributor), Ackerman, Margaret E. (Author), Bailey-Kellogg, Chris (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2015-05-28T18:07:58Z.
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