A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in culture versus in their native microenvironment. Specifically, we identified ma...

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Main Authors: Meacham, Corbin Elizabeth (Contributor), Lawton, Lee N. (Author), Pritchard, Justin R. (Contributor), Ehrenberger, Tobias (Contributor), Fenouille, Nina (Contributor), Zuber, Johannes (Author), Williams, Richard T. (Author), Young, Richard A. (Contributor), Soto Feliciano, Yadira Marie (Contributor), Hemann, Michael (Contributor), Joughin, Brian Alan (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Joughin, Brian A. (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory Press, 2015-09-08T15:58:32Z.
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