Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles

Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles

Regulating molecular interactions in the T-cell synapse to prevent autoimmunity or, conversely, to boost anti-tumor immunity has long been a goal in immunotherapy. However, delivering therapeutically meaningful doses of immune-modulating compounds into the synapse represents a major challenge. Here,...

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Bibliographic Details
Main Authors: Stephan, Matthias T. (Contributor), Stephan, Sirkka B. (Contributor), Bak, Peter (Contributor), Chen, Jianzhu (Contributor), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-23T13:42:54Z.
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