Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants
Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake into lymphatics/draining lymph nodes (dLNs) and instead is rapidly distributed to the bloodstream, leading to systemi...
Main Authors: | , , , , , , , , |
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Other Authors: | , , , , , , |
Format: | Article |
Language: | English |
Published: |
American Society for Clinical Investigation,
2015-10-23T18:06:21Z.
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Subjects: | |
Online Access: | Get fulltext |