Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants

Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants

Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected s.c. shows minimal uptake into lymphatics/draining lymph nodes (dLNs) and instead is rapidly distributed to the bloodstream, leading to systemi...

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Main Authors: Crespo, Monica P. (Contributor), Abraham, Wuhbet (Contributor), Chen, Stephanie H. (Contributor), Mueller, Stefanie (Contributor), Moynihan, Kelly Dare (Contributor), Melo, Mariane Bandeira (Contributor), Irvine, Darrell J (Author), Szeto, Gregory (Author), Hanson, Melissa Catherine (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hanson, Melissa C. (Contributor), Szeto, Gregory Lee (Contributor), Irvine, Darrell J. (Contributor)
Format: Article
Language:English
Published: American Society for Clinical Investigation, 2015-10-23T18:06:21Z.
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