Population pharmacokinetic–pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers

PB2452, a neutralizing monoclonal antibody fragment that binds the antiplatelet drug ticagrelor with high affinity, is being developed as a ticagrelor reversal agent. To identify a clinically useful intravenous (i.v.) reversal regimen, a semimechanistic exposure-response model was developed during t...

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Bibliographic Details
Main Authors:	Arnold, S.E (Author), Bhatt, D.L (Author), Kathman, S.J (Author), Lee, J.S (Author), Wheeler, J.J (Author)
Format:	Article
Language:	English
Published:	American Society for Clinical Pharmacology and Therapeutics 2022
Subjects:	administration and dosage adolescent Adolescent adult Adult aged alanine aminotransferase alkaline phosphatase Anticoagulation Reversal antiplatelet activity antithrombocytic agent Article aspartate aminotransferase Bayes theorem Bayes Theorem bentracimab biological model Blood Platelets Broadly Neutralizing Antibodies clinical trial controlled study demography dose response Dose-Response Relationship, Drug double blind procedure Double-Blind Method drug effect drug efficacy drug half life drug safety drug therapy estimated glomerular filtration rate female Female Healthy Volunteers hematocrit human human experiment Humans immunoglobulin fragment Immunoglobulin Fragments liver function test major clinical study male Male middle aged Middle Aged Models, Biological normal human PB-2452 pharmacology phase 1 clinical trial placebo Platelet Aggregation Inhibitors platelet reactivity prediction procedures randomized controlled trial simulation thrombocyte thrombocyte activation thrombocyte aggregation ticagrelor Ticagrelor vasodilator stimulated phosphoprotein young adult Young Adult
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Population pharmacokinetic–pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers

Internet

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