Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naïve patients with major depressive disorder

Previous neuroimaging studies have revealed abnormal functional connectivity of brain networks in patients with major depressive disorder (MDD), but findings have been inconsistent. A recent big-data study found abnormal intrinsic functional connectivity within the default mode network in patients w...

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Bibliographic Details
Main Authors:	Castellanos, F.X (Author), Li, J.-T (Author), Li, K. (Author), Li, L. (Author), Si, T.-M (Author), Su, Y.-A (Author), Wu, Y.-K (Author), Yan, C.-G (Author)
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2021
Subjects:	adult Adult adverse event antidepressant activity antidepressant agent antidepressants Antidepressive Agents Article big data brain cortex brain network Cerebral Cortex clinical assessment clinical trial connectome Connectome controlled study cross-sectional study default mode network Default Mode Network Depressive Disorder, Major diagnostic imaging drug dose titration drug effect drug efficacy duloxetine Duloxetine Hydrochloride escitalopram Escitalopram female Female follow up Follow-Up Studies functional connectivity Hamilton Depression Rating Scale human Humans longitudinal study Magnetic Resonance Imaging major clinical study major depression major depressive disorder male Male mini international neuropsychiatric interview nerve cell network Nerve Net neuroimaging nuclear magnetic resonance imaging pathophysiology priority journal resting state network resting-state fMRI treatment duration treatment outcome Treatment Outcome treatment withdrawal young adult Young Adult
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Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naïve patients with major depressive disorder

Internet

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