The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors

The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors

Epoxide hydrolases (EHs) are enzymes involved in the metabolism of endogenous and exogenous epoxides, and the development of EH inhibitors has important applications in the medicine. In humans, EH inhibitors are being tested in the treatment of cardiovascular diseases and show potent anti-inflammato...

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Bibliographic Details
Main Authors: Adriani, P.P (Author), Chambergo, F.S (Author), de Oliveira, G.S (Author), Dias, M.V.B (Author), Hammock, B.D (Author), Morisseau, C. (Author), Ribeiro, J.A (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2019
Subjects:
amide
Amides
antagonists and inhibitors
antifungal agent
Article
Catalytic Domain
chemistry
Crystal structure
crystallography
drug design
drug effect
enzyme active site
enzyme conformation
enzyme inhibitor
Enzyme Inhibitors
enzymology
epoxide hydrolase
Epoxide hydrolase
Epoxide Hydrolases
fungal metabolism
fungal virulence
human
Hypocrea jecorina
IC50
Inhibitors
Inhibitory Concentration 50
metabolism
Models, Molecular
molecular model
nonhuman
protein analysis
protein interaction
protein structure
Trichoderma
Trichoderma reesei
urea
Urea
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