Drug-induced resistance evolution necessitates less aggressive treatment

Drug-induced resistance evolution necessitates less aggressive treatment

Increasing body of experimental evidence suggests that anticancer and antimicrobial therapies may themselves promote the acquisition of drug resistance by increasing mutability. The successful control of evolving populations requires that such biological costs of control are identified, quantified a...

Full description

Bibliographic Details
Main Authors: Beerenwinkel, N. (Author), Cairns, J. (Author), Kuosmanen, T. (Author), Mononen, T. (Author), Mustonen, V. (Author), Noble, R. (Author)
Format: Article
Language:English
Published: Public Library of Science 2021
Subjects:
antibiotic resistance
antiinfective agent
Anti-Infective Agents
antineoplastic agent
Antineoplastic Agents
Article
biological model
biology
clinical practice
Computational Biology
computer simulation
Computer Simulation
dose response
Dose-Response Relationship, Drug
drug effect
drug resistance
Drug Resistance, Microbial
Drug Resistance, Neoplasm
evolution
Evolution, Molecular
genetics
growth rate
health care cost
health care quality
Host Microbial Interactions
human
Humans
Markov chain
mathematical model
Models, Biological
molecular evolution
mutagenicity
mutation
Mutation
mutation rate
Mutation Rate
neoplasm
Neoplasms
pharmacodynamics
phenotype
Phenotype
Stochastic Processes
treatment outcome
treatment planning
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items