Safety assessment of two new Lactobacillus strains as probiotic for human using a rat model

Safety assessment of two new Lactobacillus strains as probiotic for human using a rat model

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Two previously isolated Lactobacillus strains (L. fermentum HM3 from human milk and L. buchneri FD2 from fermented dates), intended as probiotic for human, were assessed for their safety using acute and subacute oral toxicity tests in rats. In addition, their effects on cecal microflora and harmful...

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Bibliographic Details
Main Authors: Faseleh Jahromi, M. (Author), Ho, Y.W (Author), Kalavathy, R. (Author), Liang, J.B (Author), Shokryazdan, P. (Author), Sieo, C.C (Author)
Format: Article
Language:English
Published: Public Library of Science 2016
Subjects:
acute toxicity
animal
animal experiment
animal model
animal tissue
Animals
Article
bacterial enzyme
bacterial growth
bacterial strain
bacterium identification
beta glucosidase
beta glucuronidase
biochemistry
blood analysis
blood component
body weight
Body Weight
cecum
Cecum
controlled study
drug effect
enzyme activity
enzyme assay
enzymology
feeding behavior
Feeding Behavior
female
Female
food intake
growth rate
histopathology
human
Humans
intestine flora
Lactobacillus
Lactobacillus buchneri
Lactobacillus fermentum
male
Male
microbiology
Models, Animal
molecular dynamics
nonhuman
oral toxicity
organ weight
probiotic agent
Probiotics
rat
Rats
Rats, Sprague-Dawley
risk assessment
species difference
Species Specificity
Sprague Dawley rat
toxicity
toxicity testing
Toxicity Tests
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