Synthesis and α-glucosidase inhibition activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2h-benzo[e][1,2]thiazin-2-yl]-n-arylacetamides: An in silico and biochemical approach

Synthesis and α-glucosidase inhibition activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2h-benzo[e][1,2]thiazin-2-yl]-n-arylacetamides: An in silico and biochemical approach

Diabetes mellitus (DM) is a chronic disorder and has affected a large number of people worldwide. Insufficient insulin production causes an increase in blood glucose level that results in DM. To lower the blood glucose level, various drugs are employed that block the activity of the α-glucosidase en...

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Bibliographic Details
Main Authors: Ahmad, M. (Author), Ashfaq, U.A (Author), Aslam, S. (Author), Hussain, M. (Author), Lee, D.S (Author), Muddassar, M. (Author), Saddique, F.A (Author), Sultan, S. (Author), Taj, S. (Author), Zaki, M.E.A (Author)
Format: Article
Language:English
Published: MDPI AG 2021
Series:Molecules
Subjects:
1,2-Benzothiazines
acetamide derivative
Acetamides
Anti-diabetic
antidiabetic agent
chemistry
computer simulation
Computer Simulation
diabetes mellitus
Diabetes Mellitus
Drug Evaluation, Preclinical
glycosidase inhibitor
Glycoside Hydrolase Inhibitors
human
Humans
Hypoglycemic Agents
IC50
Inhibitory Concentration 50
molecular docking
Molecular docking
Molecular Docking Simulation
preclinical study
structure activity relation
Structure-Activity Relationship
synthesis
Synthesis
thiazine derivative
Thiazines
α-glucosidase inhibition
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