Discovery of amide-functionalized benzimidazolium salts as potent α-glucosidase inhibitors

Discovery of amide-functionalized benzimidazolium salts as potent α-glucosidase inhibitors

α-Glucosidase inhibitors (AGIs) are used as medicines for the treatment of diabetes mellitus. The α-Glucosidase enzyme is present in the small intestine and is responsible for the breakdown of carbohydrates into sugars. The process results in an increase in blood sugar levels. AGIs slow down the dig...

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Bibliographic Details
Main Authors: Ahmad, M. (Author), Ashfaq, U.A (Author), Khan, I.A (Author), Sultan, S. (Author), Zaki, M.E.A (Author)
Format: Article
Language:English
Published: MDPI AG 2021
Series:Molecules
Subjects:
alpha glucosidase
alpha-Glucosidases
amide
Amides
Anti-diabetic studies
benzimidazole
benzimidazole derivative
Benzimidazole derivatives
Benzimidazoles
Benzimidazolium salts
Catalytic Domain
chemistry
drug design
Drug Design
enzyme active site
glycosidase inhibitor
Glycoside Hydrolase Inhibitors
inorganic salt
kinetics
Kinetics
metabolism
molecular docking
Molecular docking
Molecular Docking Simulation
Salts
structure activity relation
Structure-Activity Relationship
α-glucosidase inhibition
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