An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

by Emil Dandanell Agerschou, Patrick Flagmeier, Theodora Saridaki, Céline Galvagnion, Daniel Komnig, Laetitia Heid, Vibha Prasad, Hamed Shaykhalishahi, Dieter Willbold, Christopher M Dobson, Aaron Voigt, Bjoern Falkenburger, Wolfgang Hoyer, Alexander K Buell
Published 2019-08-01

Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils.

by Mookyung Cheon, Iksoo Chang, Sandipan Mohanty, Leila M Luheshi, Christopher M Dobson, Michele Vendruscolo, Giorgio Favrin
Published 2007-09-01

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.

by Leila M Luheshi, Gian Gaetano Tartaglia, Ann-Christin Brorsson, Amol P Pawar, Ian E Watson, Fabrizio Chiti, Michele Vendruscolo, David A Lomas, Christopher M Dobson, Damian C Crowther
Published 2007-10-01

Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation.

by Anthony W Fitzpatrick, Tuomas P J Knowles, Christopher A Waudby, Michele Vendruscolo, Christopher M Dobson
Published 2011-10-01

Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.

by Minkoo Ahn, Erwin De Genst, Gabriele S Kaminski Schierle, Miklos Erdelyi, Clemens F Kaminski, Christopher M Dobson, Janet R Kumita
Published 2012-01-01

Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.

by Leila M Luheshi, Wolfgang Hoyer, Teresa Pereira de Barros, Iris van Dijk Härd, Ann-Christin Brorsson, Bertil Macao, Cecilia Persson, Damian C Crowther, David A Lomas, Stefan Ståhl, Christopher M Dobson, Torleif Härd
Published 2010-03-01

Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response.

by Tessa Sinnige, Prashanth Ciryam, Samuel Casford, Christopher M Dobson, Mario de Bono, Michele Vendruscolo
Published 2019-01-01

A simple lattice model that captures protein folding, aggregation and amyloid formation.

by Sanne Abeln, Michele Vendruscolo, Christopher M Dobson, Daan Frenkel
Published 2014-01-01