Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

by Chen, Walter W., Marjanovic, Nemanja, Zoncu, Roberto, Katajisto, Pekka, Dohla, Julia, Chaffer, Christine L., Pentinmikko, Nalle, Iqbal, Sharif, Weinberg, Robert A, Sabatini, David
Published 2015

Amino acids and mTORC1: from lysosomes to disease

by Efeyan, Alejo, Zoncu, Roberto, Sabatini, David
Published 2017

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

by Lamming, Dudley W., Ye, Lan, Katajisto, Pekka, Goncalves, Marcus D., Saitoh, Maki, Stevens, Deanna M., Davis, James G., Salmon, Adam B., Richardson, Arlan, Ahima, Rexford S., Guertin, David A., Baur, Joseph A., Sabatini, David
Published 2014

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

by Settembre, Carmine, Zoncu, Roberto, Medina, Diego L., Vetrini, Francesco, Erdin, Serkan, Erdin, SerpilUckac, Huynh, Tuong, Ferron, Mathieu, Karsenty, Gerard, Vellard, Michel C., Facchinetti, Valeria, Ballabio, Andrea, Ballabio, Andrea, Sabatini, David
Published 2015

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

by Kami, Kenjiro, Shelton, Laura M., Ramkissoon, Shakti H., Ligon, Keith L., Snuderl, Matija, Kim, Dohoon, Fiske, Brian Prescott, Birsoy, Kivanc, Freinkman, Elizaveta, Possemato, Richard, Chudnovsky, Yakov, Chen, Walter W., Cantor, Jason R., Gui, Dan Yi, Kwon, ManJae, Kang, Seong Woo, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Published 2017

Nutrient-sensing mechanisms and pathways

by Efeyan, Alejo, Comb, William C., Sabatini, David
Published 2015

mTOR Signaling in Growth Control and Disease

by Laplante, Mathieu, Sabatini, David M, Sabatini, David
Published 2014

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

by Robida-Stubbs, Stacey, Glover-Cutter, Kira, Lamming, Dudley W, Mizunuma, Masaki, Narasimhan, Sri Devi, Neumann-Haefelin, Elke, Sabatini, David M, Blackwell, T. Keith, Lamming, Dudley W., Sabatini, David
Published 2014

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

by Mihaylova, Maria M, Sabatini, David M, Yilmaz, Omer, Mihaylova, Maria M., Sabatini, David
Published 2016

mTOR and cancer: many loops in one pathway

by Efeyan, Alejo, Sabatini, David
Published 2012

Growth signaling at the nexus of stem cell life and death

by Wood, Kris C., Sabatini, David
Published 2009

Rictor Phosphorylation on the THR-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2

by Boulbes, Delphine, Chen, Chien-Hung, Shaikenov, Tattym, Agarwal, Nitin K., Addona, Terri A., Keshishian, Hasmik, Carr, Steven A., Magnuson, Mark A., Sarbassov, Dos D., Sabatini, David, Peterson, Timothy Richard
Published 2012

The TSC-mTOR pathway regulates macrophage polarization

by Byles, Vanessa, Covarrubias, Anthony J., Ben-Sahra, Issam, Lamming, Dudley W., Manning, Brendan D., Horng, Tiffany, Sabatini, David
Published 2015

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

by Mercken, Evi M., Crosby, Seth D., Lamming, Dudley W., JeBailey, Lellean, Krzysik-Walker, Susan, Villareal, Dennis T., Capri, Miriam, Franceschi, Claudio, Zhang, Yongqing, Becker, Kevin, de Cabo, Rafael, Fontana, Luigi, Sabatini, David
Published 2015

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

by Saadatpour, Assieh, Hong, Sue-Jean, Pinello, Luca, Katz, Yarden, Lamming, Dudley W., Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Beyaz, Semir, Mana, Miyeko, Roper, Jatin, Kedrin, Dmitriy, Bauer-Rowe, Khristian E., Xifaras, Michael, Akkad, Adam, Arias, Erika, Shinagare, Shweta, Abu-Remaileh, Monther, Dogum, Rizkullah, Sabatini, David, Yilmaz, Omer, Mihaylova, Maria M.
Published 2017

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

by Guertin, David A., Stevens, Deanna M., Saitoh, Maki, Kinkel, Stephanie, Crosby, Katherine, Sheen, Joon-Ho, Mullholland, David J., Magnuson, Mark A., Wu, Hong, Sabatini, David, Stevens, Deanna M.
Published 2015

Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens

by Wang, Tim, Lander, Eric Steven, Sabatini, David
Published 2016

Cancer Cell Metabolism: One Hallmark, Many Faces

by Cantor, Jason R., Sabatini, David
Published 2015

mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis

by Laplante, Mathieu, Sabatini, David
Published 2011

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

by Grabiner, Brian C., Nardi, Valentina, Birsoy, Kivanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H., Sabatini, David
Published 2015