mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis

by Laplante, Mathieu, Sabatini, David
Published 2011

Structure of the human mTOR Complex I and its implications for rapamycin inhibition

by Yip, Calvin K., Murata, Kazuyoshi, Walz, Thomas, Kang, Seong A., Sabatini, David
Published 2012

Identification of an oncogenic RAB protein

by Wheeler, D. B., Zoncu, R., Root, D. E., Sawyers, C. L., Sabatini, David
Published 2017

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

by Cantor, Jason R., Abu-Remaileh, Monther, Kanarek, Naama, Freinkman, Elizaveta, Gao, Xin, Louissaint, Abner, Lewis, Caroline A., Sabatini, David
Published 2018

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

by Sabatini, David, Wolfson, Rachel Laura, Efeyan, Alejo
Published 2017

Nutrient-sensing mechanisms and pathways

by Efeyan, Alejo, Comb, William C., Sabatini, David
Published 2015

Nutrients versus growth factors in mTORC1 activation

by Efeyan, Alejo, Sabatini, David M, Sabatini, David
Published 2015

DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity

by Laplante, Mathieu, Horvat, Simon, Festuccia, William T., Birsoy, Kivanc, Prevorsek, Zala, Efeyan, Alejo, Sabatini, David M, Sabatini, David
Published 2014

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

by Dominguez-Brauer, Carmen, Hao, Zhenyue, Elia, Andrew J, Fortin, Jérôme M, Nechanitzky, Robert, Brauer, Patrick M, Sheng, Yi, Chio, Iok In Christine, Haight, Jillian, Pollett, Aaron, Cairns, Robert, Tworzyanski, Leanne, Inoue, Satoshi, Reardon, Colin, Marques, Ana, Silvester, Jennifer, Cox, Maureen A, Wakeham, Andrew, van Es, Johan H, Clevers, Hans, Sato, Toshiro, Mak, Tak W, Mana, Miyeko, Yilmaz, Omer, Sabatini, David
Published 2018

Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treat...

by Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Gray, Nathanael S., Sabatini, David
Published 2012

Amino acids and mTORC1: from lysosomes to disease

by Efeyan, Alejo, Zoncu, Roberto, Sabatini, David
Published 2017

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

by Chan, Sze Ham, Freinkman, Elizaveta, Abu-Remaileh, Monther, Wyant, Gregory Andrew, Kim, Choah, Laqtom, Nouf N, Abbasi, Maria, Sabatini, David
Published 2019

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

by Ersching, Jonatan, Efeyan, Alejo, Mesin, Luka, Jacobsen, Johanne T., Pasqual, Giulia, Grabiner, Brian C., Dominguez-Sola, David, Victora, Gabriel D., Sabatini, David
Published 2018

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

by Muranen, Taru, Selfors, Laura M., Hwang, Julie, Gallegos, Lisa L., Coloff, Jonathan L., Mills, Gordon B., Brugge, Joan S., Thoreen, Carson C, Kang, Seong-Cheol, Sabatini, David
Published 2018

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae

by Liu, Qingsong, Ren, Tao, Fresques, Tara, Oppliger, Wolfgang, Niles, Brad J., Hur, Wooyoung, Hall, Michael N., Powers, Ted, Gray, Nathanael S., Sabatini, David
Published 2015

The TSC-mTOR pathway regulates macrophage polarization

by Byles, Vanessa, Covarrubias, Anthony J., Ben-Sahra, Issam, Lamming, Dudley W., Manning, Brendan D., Horng, Tiffany, Sabatini, David
Published 2015

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

by Mihaylova, Maria M, Sabatini, David M, Yilmaz, Omer, Mihaylova, Maria M., Sabatini, David
Published 2016

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

by Yu, Haiyan, Hughes, Nicholas W., Kendirli, Arek, Klein, Klara, Lander, Eric S., Wang, Tim, Liu, Bingxu, Chen, Walter W., Sabatini, David
Published 2018

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

by Freinkman, Elizaveta, Wang, Tim, Chen, Walter W., Abu-Remaileh, Monther, Sabatini, David, Birsoy, Kivanc
Published 2017

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

by Mercken, Evi M., Crosby, Seth D., Lamming, Dudley W., JeBailey, Lellean, Krzysik-Walker, Susan, Villareal, Dennis T., Capri, Miriam, Franceschi, Claudio, Zhang, Yongqing, Becker, Kevin, de Cabo, Rafael, Fontana, Luigi, Sabatini, David
Published 2015