Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis

by Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius, Hannelore Ehrenreich
Published 2021-07-01

Molecular diagnostics helps to identify distinct subgroups of spinal astrocytomas

by Annamaria Biczok, Felix L. Strübing, Julia M. Eder, Rupert Egensperger, Oliver Schnell, Stefan Zausinger, Julia E. Neumann, Jochen Herms, Joerg-Christian Tonn, Mario M. Dorostkar
Published 2021-06-01

Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literatu...

by Aydan Kahriman, James Bouley, Thomas W. Smith, Daryl A. Bosco, Amanda L. Woerman, Nils Henninger
Published 2021-06-01

Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer’s disease

by Ceren Emre, Khanh V. Do, Bokkyoo Jun, Erik Hjorth, Silvia Gómez Alcalde, Marie-Audrey I. Kautzmann, William C. Gordon, Per Nilsson, Nicolas G. Bazan, Marianne Schultzberg
Published 2021-06-01

Correction to: Hsp90 co‑chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild‑type mice

by Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair
Published 2021-05-01

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice

by Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Published 2021-05-01

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

by Xiao Zhang, Paul O’Callaghan, Honglian Li, Yingxia Tan, Ganlin Zhang, Uri Barash, Xiaomin Wang, Lars Lannfelt, Israel Vlodavsky, Ulf Lindahl, Jin-Ping Li
Published 2021-05-01

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

by Ethan W. Hass, Zachary A. Sorrentino, Grace M. Lloyd, Nikolaus R. McFarland, Stefan Prokop, Benoit I. Giasson
Published 2021-05-01

Early onset senescence and cognitive impairment in a murine model of repeated mTBI

by Nicole Schwab, YoungJun Ju, Lili-Naz Hazrati
Published 2021-05-01

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis

by Kevin Peikert, Enrica Federti, Alessandro Matte, Gabriela Constantin, Enrica Caterina Pietronigro, Paolo Francesco Fabene, Paola Defilippi, Emilia Turco, Federico Del Gallo, Pietro Pucci, Angela Amoresano, Anna Illiano, Flora Cozzolino, Maria Monti, Francesca Garello, Enzo Terreno, Seth Leo Alper, Hannes Glaß, Lisann Pelzl, Katja Akgün, Tjalf Ziemssen, Rainer Ordemann, Florian Lang, Anna Maria Brunati, Elena Tibaldi, Immacolata Andolfo, Achille Iolascon, Giuseppe Bertini, Mario Buffelli, Carlo Zancanaro, Erika Lorenzetto, Angela Siciliano, Massimiliano Bonifacio, Adrian Danek, Ruth Helen Walker, Andreas Hermann, Lucia De Franceschi
Published 2021-05-01

DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

by Byung Woo Kim, Ye Eun Jeong, Margaret Wong, Lee J. Martin
Published 2020-01-01

Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology

by Lucia A. A. Giannini, Claire Peterson, Daniel Ohm, Sharon X. Xie, Corey T. McMillan, Katya Raskovsky, Lauren Massimo, EunRah Suh, Vivianna M. Van Deerlin, David A. Wolk, John Q. Trojanowski, Edward B. Lee, Murray Grossman, David J. Irwin
Published 2021-02-01

Differentiated glioblastoma cells accelerate tumor progression by shaping the tumor microenvironment via CCN1-mediated macrophage infiltration

by Atsuhito Uneda, Kazuhiko Kurozumi, Atsushi Fujimura, Kentaro Fujii, Joji Ishida, Yosuke Shimazu, Yoshihiro Otani, Yusuke Tomita, Yasuhiko Hattori, Yuji Matsumoto, Nobushige Tsuboi, Keigo Makino, Shuichiro Hirano, Atsunori Kamiya, Isao Date
Published 2021-02-01

A novel recessive mutation affecting DNAJB6a causes myofibrillar myopathy

by Fang-Yuan Qian, Yu-Dong Guo, Juan Zu, Jin-Hua Zhang, Yi-Ming Zheng, Idriss Ali Abdoulaye, Zhao-Hui Pan, Chun-Ming Xie, Han-Chao Gao, Zhi-Jun Zhang
Published 2021-02-01

The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas

by Matthew McCord, Alicia Steffens, Rodrigo Javier, Kwok-Ling Kam, Kathleen McCortney, Craig Horbinski
Published 2020-02-01

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

by Chris McKinnon, Mitchell L. De Snoo, Elise Gondard, Clemens Neudorfer, Hien Chau, Sophie G. Ngana, Darren M. O’Hara, Jonathan M. Brotchie, James B. Koprich, Andres M. Lozano, Lorraine V. Kalia, Suneil K. Kalia
Published 2020-02-01

Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson’s disease

by Stefanie Smolders, Stéphanie Philtjens, David Crosiers, Anne Sieben, Elisabeth Hens, Bavo Heeman, Sara Van Mossevelde, Philippe Pals, Bob Asselbergh, Roberto Dos Santos Dias, Yannick Vermeiren, Rik Vandenberghe, Sebastiaan Engelborghs, Peter Paul De Deyn, Jean-Jacques Martin, Patrick Cras, Wim Annaert, Christine Van Broeckhoven, BELNEU consortium
Published 2021-02-01

Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels

by Xuanhui Liu, Chuang Gao, Jiangyuan Yuan, Tangtang Xiang, Zhitao Gong, Hongliang Luo, Weiwei Jiang, Yiming Song, Jinhao Huang, Wei Quan, Dong Wang, Ye Tian, Xintong Ge, Ping Lei, Jianning Zhang, Rongcai Jiang
Published 2020-02-01

Three-dimensional vascular microenvironment landscape in human glioblastoma

by George P. Cribaro, Elena Saavedra-López, Leire Romarate, Izaskun Mitxitorena, Laura R. Díaz, Paola V. Casanova, Meritxell Roig-Martínez, José M. Gallego, Ana Perez-Vallés, Carlos Barcia
Published 2021-02-01

Alzheimer’s disease brain contains tau fractions with differential prion-like activities

by Longfei Li, Ruirui Shi, Jianlan Gu, Yunn Chyn Tung, Yan Zhou, Dingwei Zhou, Ruozhen Wu, Dandan Chu, Nana Jin, Kevin Deng, Jiawei Xu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Published 2021-02-01