Phenformin as an Anticancer Agent: Challenges and Prospects

by Mª Eugenia García Rubiño, Esmeralda Carrillo, Gloria Ruiz Alcalá, Alicia Domínguez-Martín, Juan A. Marchal, Houria Boulaiz
Published 2019-07-01

Synergistic anti-cancer effect of phenformin and oxamate.

by W Keith Miskimins, Hyun Joo Ahn, Ji Yeon Kim, Sun Ryu, Yuh-Seog Jung, Joon Young Choi
Published 2014-01-01

Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways

by Yanjun Huang, Sichun Zhou, Caimei He, Jun Deng, Ting Tao, Qiongli Su, Kwame Oteng Darko, Mei Peng, Xiaoping Yang
Published 2018-07-01

Phenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo

by Wang Y, Meng Y, Zhang S, Wu H, Yang D, Nie C, Hu Q
Published 2018-09-01

The antitumor properties of metformin and phenformin reflect their ability to inhibit the actions of differentiated embryo chondrocyte 1

by Kuo CL, Hsieh Li SM, Liang SY, Liu ST, Huang LC, Wang WM, Yen LC, Huang SM
Published 2019-07-01

Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth

by Mei Peng, Mei Peng, Jun Deng, Sichun Zhou, Di Xiao, Jiahui Long, Nan Zhang, Caimei He, Miao Mo, Xiaoping Yang
Published 2019-10-01

Phenformin Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice without Affecting Immune Cell Infiltration

by Mikkel Ø. Nørgård, Michael Christensen, Henricus A.M. Mutsaers, Rikke Nørregaard
Published 2020-03-01

Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells

by Davoud Jafari-Gharabaghlou, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Ali Mota, Soheila Vafajouy-Jamshidi, Leila Faramarzi, Sara Rasouli, Nosratollah Zarghami
Published 2018-11-01

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

by Laura Di Magno, Simona Manni, Fiorella Di Pastena, Sonia Coni, Alberto Macone, Sara Cairoli, Manolo Sambucci, Paola Infante, Marta Moretti, Marialaura Petroni, Carmine Nicoletti, Carlo Capalbo, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Luca Battistini, Bianca Maria Goffredo, Egidio Iorio, Enzo Agostinelli, Marella Maroder, Gianluca Canettieri
Published 2020-02-01

The Surprising Effect of Phenformin on Cutaneous Darkening and Characterization of Its Underlying Mechanism by a Forward Chemical Genetics Approach

by Kei Takano, Akira Hachiya, Daiki Murase, Akiko Kawasaki, Hirokazu Uda, Shinya Kasamatsu, Yoshiya Sugai, Yoshito Takahashi, Tadashi Hase, Atsushi Ohuchi, Tamio Suzuki
Published 2020-02-01

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

by Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. Grahame Hardie
Published 2019-04-01

Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury

by Kristina Skemiene, Evelina Rekuviene, Aiste Jekabsone, Paulius Cizas, Ramune Morkuniene, Vilmante Borutaite
Published 2020-10-01

Phenformin and ataxia‐telangiectasia mutated inhibitors synergistically co‐suppress liver cancer cell growth by damaging mitochondria

by Tianyu Wu, Sichun Zhou, Mei Qin, Jing Tang, Xinjian Yan, Lingli Huang, Meiyuan Huang, Jun Deng, Di Xiao, Xin Hu, Jingtao Wu, Xiaoping Yang, Gaofeng Li
Published 2021-05-01

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

by Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel
Published 2021-06-01

The Pituitary Gland is a Novel Major Site of Action of Metformin in Non-Human Primates: a Potential Path to Expand and Integrate Its Metabolic Actions

by Mari C. Vázquez-Borrego, Antonio C. Fuentes-Fayos, Manuel D. Gahete, Justo P. Castaño, Rhonda D. Kineman, Raúl M. Luque
Published 2018-09-01

Metabolic Profiles Associated With Metformin Efficacy in Cancer

by Sylvia Andrzejewski, Sylvia Andrzejewski, Peter M. Siegel, Peter M. Siegel, Julie St-Pierre
Published 2018-08-01

The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in <i>KRAS</i>-Driven Lung Cancer

by Seon-Hyeong Lee, Yoon Jeon, Joon Hee Kang, Hyonchol Jang, Ho Lee, Soo-Youl Kim
Published 2020-05-01

Statistically controlled identification of differentially expressed genes in one-to-one cell line comparisons of the CMAP database for drug repositioning

by Jun He, Haidan Yan, Hao Cai, Xiangyu Li, Qingzhou Guan, Weicheng Zheng, Rou Chen, Huaping Liu, Kai Song, Zheng Guo, Xianlong Wang
Published 2017-09-01

Effects of Metformin on Spontaneous Ca²⁺ Signals in Cultured Microglia Cells under Normoxic and Hypoxic Conditions

by Silvija Jankeviciute, Natasa Svirskiene, Gytis Svirskis, Vilmante Borutaite
Published 2021-08-01