Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

by David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Published 2018-08-01

Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

by David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Published 2020-10-01

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

by David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Published 2020-10-01

Administration of panobinostat is associated with increased IL-17A mRNA in the intestinal epithelium of HIV-1 patients

by A. Bjerg Christensen, A. Dige, J. Randel Nyengaard, J. Agnholt, P.W. Denton
Published 2015-12-01

Corrigendum: Effect of Aerosolization and Drying on the Viability of Pseudomonas syringae Cells

by Malin Alsved, Malin Alsved, Stine Holm, Stine Holm, Sigurd Christiansen, Mads Smidt, Mads Smidt, Bernadette Rosati, Meilee Ling, Meilee Ling, Thomas Boesen, Kai Finster, Kai Finster, Merete Bilde, Jakob Löndahl, Jakob Löndahl, Tina Šantl-Temkiv, Tina Šantl-Temkiv, Tina Šantl-Temkiv
Published 2019-10-01

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

by Camilla Gustafsen, Ditte Olsen, Joachim Vilstrup, Signe Lund, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup
Published 2017-09-01

Brain proteome changes in female Brd1+/− mice unmask dendritic spine pathology and show enrichment for schizophrenia risk

by Veerle Paternoster, Maria Svanborg, Anders Valdemar Edhager, Anto P. Rajkumar, Esben Ahlburg Eickhardt, Jonatan Pallesen, Jakob Grove, Per Qvist, Tue Fryland, Gregers Wegener, Jens Randel Nyengaard, Ole Mors, Johan Palmfeldt, Anders Dupont Børglum, Jane Hvarregaard Christensen
Published 2019-04-01

Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

by A. Laustsen, R. O. Bak, C. Krapp, L. Kjær, J. H. Egedahl, C. C. Petersen, S. Pillai, H. Q. Tang, N. Uldbjerg, M. Porteus, N. R. Roan, M. Nyegaard, P. W. Denton, M. R. Jakobsen
Published 2018-08-01

SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity

by Stine SF Nielsen, Line K Vibholm, Ida Monrad, Rikke Olesen, Giacomo S Frattari, Marie H Pahus, Jesper F Højen, Jesper D Gunst, Christian Erikstrup, Andreas Holleufer, Rune Hartmann, Lars Østergaard, Ole S Søgaard, Mariane H Schleimann, Martin Tolstrup
Published 2021-06-01

SARS-CoV-2 persistence is associated with antigen-specific CD8 T-cell responses

by Line K. Vibholm, Stine S.F. Nielsen, Marie H. Pahus, Giacomo S. Frattari, Rikke Olesen, Rebecca Andersen, Ida Monrad, Anna H.F. Andersen, Michelle M. Thomsen, Christina V. Konrad, Sidsel D. Andersen, Jesper F. Højen, Jesper D. Gunst, Lars Østergaard, Ole S. Søgaard, Mariane H. Schleimann, Martin Tolstrup
Published 2021-02-01

Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association

by Hossein Mohammad-Beigi, Yuya Hayashi, Christina Moeslund Zeuthen, Hoda Eskandari, Carsten Scavenius, Kristian Juul-Madsen, Thomas Vorup-Jensen, Jan J. Enghild, Duncan S. Sutherland
Published 2020-09-01

Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19

by Madalina Elena Carter-Timofte, Madalina Elena Carter-Timofte, Sofie Eg Jørgensen, Sofie Eg Jørgensen, Mette Ratzer Freytag, Mette Ratzer Freytag, Michelle Mølgaard Thomsen, Michelle Mølgaard Thomsen, Nanna-Sophie Brinck Andersen, Nanna-Sophie Brinck Andersen, Ali Al-Mousawi, Ali Al-Mousawi, Alon Schneider Hait, Alon Schneider Hait, Trine H. Mogensen, Trine H. Mogensen, Trine H. Mogensen
Published 2020-06-01

Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.

by Jesper D. Gunst, Nina B. Staerke, Marie H. Pahus, Lena H. Kristensen, Jacob Bodilsen, Nicolai Lohse, Lars S. Dalgaard, Dorthe Brønnum, Ole Fröbert, Bo Hønge, Isik S. Johansen, Ida Monrad, Christian Erikstrup, Regitze Rosendal, Emil Vilstrup, Theis Mariager, Dorthe G. Bove, Rasmus Offersen, Shakil Shakar, Sara Cajander, Nis P. Jørgensen, Sajitha S. Sritharan, Peter Breining, Søren Jespersen, Klaus L. Mortensen, Mads L. Jensen, Lilian Kolte, Giacomo S. Frattari, Carsten S. Larsen, Merete Storgaard, Lars P. Nielsen, Martin Tolstrup, Eva A. Sædder, Lars J. Østergaard, Hien T.T. Ngo, Morten H. Jensen, Jesper F. Højen, Mads Kjolby, Ole S. Søgaard
Published 2021-05-01

Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency ex vivo without T cell activation

by Jesper D. Gunst, Kathrine Kjær, Rikke Olesen, Thomas A. Rasmussen, Lars Østergaard, Paul W. Denton, Ole S. Søgaard, Martin Tolstrup
Published 2019-07-01

Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death

by Lasse Reimer, Louise Buur Vesterager, Cristine Betzer, Jin Zheng, Lærke Dalsgaard Nielsen, Rikke Hahn Kofoed, Louise Berkhoudt Lassen, Ulrik Bølcho, Søren Riis Paludan, Karina Fog, Poul Henning Jensen
Published 2018-07-01

A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state

by Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt, Steffen Sinning, Poul Nissen
Published 2016-05-01

TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodesResearch in context

by Mariane H. Schleimann, Maria-Louise Kobberø, Line K. Vibholm, Kathrine Kjær, Leila B. Giron, Kathleen Busman-Sahay, Chi Ngai Chan, Michael Nekorchuk, Manuel Schmidt, Burghardt Wittig, Tine E. Damsgaard, Peter Ahlburg, Michel B. Hellfritzsch, Kaja Zuwala, Frederik H. Rothemejer, Rikke Olesen, Phillipp Schommers, Florian Klein, Harsh Dweep, Andrew Kossenkov, Jens R. Nyengaard, Jacob D. Estes, Mohamed Abdel-Mohsen, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard, Paul W. Denton
Published 2019-07-01

Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations

by Muwan Chen, Muyesier Maimaitili, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark Denham
Published 2020-01-01

Generation of an induced pluripotent stem cell line (DANi-011A) from a Parkinson's disease patient with a LRRK2 p.G2019S mutation

by Muwan Chen, Muyesier Maimaitili, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark Denham
Published 2020-05-01

Aarhus Regenerative Orthopaedics Symposium (AROS): Regeneration in the ageing population

by Casper B Foldager, Michael Bendtsen, Lise C Berg, Jan E Brinchmann, Mats Brittberg, Cody Bunger, Jose Canseco, Li Chen, Bjørn B Christensen, Pauline Colombier, Bent W Deleuran, James Edwards, Brian Elmengaard, Jack Farr, Birgitta Gatenholm, Andreas H Gomoll, James H Hui, Rune B Jakobsen, Natasja L Joergensen, Moustapha Kassem, Thomas Koch, Søren Kold, Michael R Krogsgaard, Henrik Lauridsen, Dang Le, Catherine Le Visage, Martin Lind, Jens V Nygaard, Morten L Olesen, Michael Pedersen, Martin Rathcke, James B Richardson, Sally Roberts, Jan H D Rölfing, Daisuke Sakai, Wei Seong Toh, Jill Urban, Myron Spector
Published 2016-12-01