Anti–SARS‐CoV‐2 Repurposing Drug Database: Clinical Pharmacology Considerations

by Xinyuan Zhang, Yuching Yang, Manuela Grimstein, Guansheng Liu, Eliford Kitabi, Jianghong Fan, Ying‐Hong Wang, Justin Earp, James L. Weaver, Hao Zhu, Jiang Liu, Kellie S. Reynolds, Shiew‐Mei Huang, Yaning Wang
Published 2021-09-01

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

by James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard, Jessie Collins, Saeed Khan, Kidon Sung, Katherine M. Tyner
Published 2017-07-01

Corrigendum: Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment

by Sara Dutta, Kelly C. Chang, Kylie A. Beattie, Jiansong Sheng, Phu N. Tran, Wendy W. Wu, Min Wu, David G. Strauss, Thomas Colatsky, Zhihua Li
Published 2017-12-01

Developing an animal model to detect drug–drug interactions impacting drug-induced respiratory depression

by Lin Xu, Ashok Chockalingam, Sharron Stewart, Katherine Shea, Murali K. Matta, Suresh Narayanasamy, Nageswara R. Pilli, Donna A. Volpe, James Weaver, Hao Zhu, Michael C. Davis, David G. Strauss, Rodney Rouse
Published 2020-01-01

Determination of Non-Transferrin Bound Iron, Transferrin Bound Iron, Drug Bound Iron and Total Iron in Serum in a Rats after IV Administration of Sodium Ferric Gluconate Complex by...

by Murali K. Matta, Christopher R. Beekman, Adarsh Gandhi, Suresh Narayanasamy, Christopher D. Thomas, Adil Mohammad, Sharron Stewart, Lin Xu, Ashok Chockalingam, Katherine Shea, Vikram Patel, Rodney Rouse
Published 2018-02-01

Comparative Evaluation of U.S. Brand and Generic Intravenous Sodium Ferric Gluconate Complex in Sucrose Injection: Biodistribution after Intravenous Dosing in Rats

by Christopher R. Beekman, Murali K. Matta, Christopher D. Thomas, Adil Mohammad, Sharron Stewart, Lin Xu, Ashok Chockalingam, Katherine Shea, Dajun Sun, Wenlei Jiang, Vikram Patel, Rodney Rouse
Published 2017-12-01

Application of Physiologically‐Based Pharmacokinetic Modeling to Predict Gastric pH‐Dependent Drug–Drug Interactions for Weak Base Drugs

by Zhongqi Dong, Jia Li, Fang Wu, Ping Zhao, Sue‐Chih Lee, Lillian Zhang, Paul Seo, Lei Zhang
Published 2020-08-01

Consideration of a Credibility Assessment Framework in Model‐Informed Drug Development: Potential Application to Physiologically‐Based Pharmacokinetic Modeling and Simulation

by Colleen Kuemmel, Yuching Yang, Xinyuan Zhang, Jeffry Florian, Hao Zhu, Million Tegenge, Shiew‐Mei Huang, Yaning Wang, Tina Morrison, Issam Zineh
Published 2020-01-01

FDA’s new pharmaceutical quality initiative: Knowledge-aided assessment & structured applications

by Lawrence X. Yu, Andre Raw, Larisa Wu, Christina Capacci-Daniel, Ying Zhang, Susan Rosencrance
Published 2019-12-01

A novel murine in vivo model for acute hereditary angioedema attacks

by Sujata Bupp, Matthew Whittaker, Mari Lehtimaki, JuMe Park, Jessica Dement-Brown, Zhao-Hua Zhou, Steven Kozlowski
Published 2021-08-01

Emergence of nosocomial associated opportunistic pathogens in the gut microbiome after antibiotic treatment

by Isaac Raplee, Lacey Walker, Lei Xu, Anil Surathu, Ashok Chockalingam, Sharron Stewart, Xiaomei Han, Rodney Rouse, Zhihua Li
Published 2021-02-01

The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

by Lei Xu, Anil Surathu, Isaac Raplee, Ashok Chockalingam, Sharron Stewart, Lacey Walker, Leonard Sacks, Vikram Patel, Zhihua Li, Rodney Rouse
Published 2020-03-01

Evaluation of the Ability of Immune Humanized Mice to Demonstrate CD20‐Specific Cytotoxicity Induced by Ofatumumab

by Kenrick M. Semple, Carlos M. Gonzaléz, Melissa Zarr, José R. Austin, Vikram Patel, Kristina E. Howard
Published 2019-05-01

Assessing CYP2C19 Ontogeny in Neonates and Infants Using Physiologically Based Pharmacokinetic Models: Impact of Enzyme Maturation Versus Inhibition

by Peng Duan, Fang Wu, Jason N. Moore, Jeffrey Fisher, Victor Crentsil, Daniel Gonzalez, Lei Zhang, Gilbert J. Burckart, Jian Wang
Published 2019-03-01

A Proposal of Conducting Bioequivalence Trials with Gastric pH Modulators for Two Oral Formulations Demonstrating Different Dissolution Profiles at Elevated pH

by Hao Zhu, Xiaomei Chen, Mariam Ahmed, Yaning Wang, Qi Liu, Ramana S. Uppoor, Colleen Kuemmel, Mehul Mehta
Published 2019-11-01

Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo

by Weiming Ouyang, Tao Xie, Hui Fang, Chunling Gao, Tzanko Stantchev, Kathleen A. Clouse, Kun Yuan, Tongzhong Ju, David M. Frucht
Published 2021-07-01

Sustained virological response rates with direct-acting antivirals in black subjects with HCV genotype 1 infection: systematic analysis of clinical trials

by Kimberly Struble, Kirk Chan-Tack, Karen Qi, Thamban Valappil, Sarah Connelly, Poonam Mishra, Dionne Price, Jeffrey Murray, Debra Birnkrant
Published 2019-07-01

Evaluation of Immunocompetent Urinary Tract Infected Balb/C Mouse Model For the Study of Antibiotic Resistance Development Using <i>Escherichia Coli</i> CFT073 Infection

by Ashok Chockalingam, Sharron Stewart, Lin Xu, Adarsh Gandhi, Murali K. Matta, Vikram Patel, Leonard Sacks, Rodney Rouse
Published 2019-09-01

Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis

by Michael A. Moses, Andrea L. George, Nozomi Sakakibara, Kanwal Mahmood, Roshini M. Ponnamperuma, Kathryn E. King, Wendy C. Weinberg
Published 2019-07-01

A headspace-gas chromatography method for isopropanol determination in warfarin sodium products as a measure of drug crystallinity

by Rahman Ziyaur, Akhtar Sohail, Siddiqui Akhtar, Ciavarella Anthony B., Nguyenpho Agnes, Faustino Patrick J., Khan Mansoor A.
Published 2018-03-01