Text-based similarity searching for hit- and lead-candidate identification

by Hähnke Volker
Published 2012-05-01

Hit-to-lead optimization of small molecules for neglected tropical disease therapeutics

Published

Hit-to-lead optimization of kinase-targeted inhibitors of Trypanosoma brucei growth

Published

Synthetic Medicinal Chemistry in Chagas’ Disease: Compounds at The Final Stage of “Hit-To-Lead” Phase

by Hugo Cerecetto, Mercedes González
Published 2010-03-01

Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.

by Patrick Baum, Ramona Schmid, Carina Ittrich, Werner Rust, Katrin Fundel-Clemens, Susanne Siewert, Martin Baur, Lisa Mara, Lore Gruenbaum, Armin Heckel, Roland Eils, Roland E Kontermann, Gerald J Roth, Florian Gantner, Andreas Schnapp, John E Park, Andreas Weith, Karsten Quast, Detlev Mennerich
Published 2010-12-01

Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness.

by Gabriel Navarro, Supchar Chokpaiboon, Geraldine De Muylder, Walter M Bray, Sean C Nisam, James H McKerrow, Khanitha Pudhom, Roger G Linington
Published 2012-01-01

Protocol for hit-to-lead optimization of compounds by auto in silico ligand directing evolution (AILDE) approach

by Longcan Mei, Fengxu Wu, Gefei Hao, Guangfu Yang
Published 2021-03-01

Design and synthesis of Quinazolinone-based libraries for inhibitation of Kinase activity and hit-to-lead optimisation of Wnt pathway inhibitors

by Quevedo, Camilo E.
Published 2008

Application of process analysis and optimization tools in hit-to-lead and lead optimization phases of drug discovery at EPP, NIBR

by Yglesias, Tatiana
Published 2010

Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.

by Maha-Hamadien Abdulla, Debbie S Ruelas, Brian Wolff, June Snedecor, Kee-Chong Lim, Fengyun Xu, Adam R Renslo, Janice Williams, James H McKerrow, Conor R Caffrey
Published 2009-07-01

In Silico/In Vitro Hit-to-Lead Methodology Yields SMYD3 Inhibitor That Eliminates Unrestrained Proliferation of Breast Carcinoma Cells

by Ilham M. Alshiraihi, Dillon K. Jarrell, Zeyad Arhouma, Kelly N. Hassell, Jaelyn Montgomery, Alyssa Padilla, Hend M. Ibrahim, Debbie C. Crans, Takamitsu A. Kato, Mark A. Brown
Published 2020-12-01

Prediction of Hit-to-Lead Ligand Molecule Interaction with G-Quadruplex DNA from c-Myc Oncogene Promoter Region

by Petar M Mitrasinovic
Published 2020-06-01

Targeting Neuronal Transcription Factor BRN2 in Neuroendocrine Tumors

by Ravi Munuganti, Daksh Thaper, Sahil Kumar, Soojin Kim, Olena Sivak, Amina Zoubeidi
Published 2019-08-01

Multiparametric Profiling for Identification of Chemosensitizers against Gram-Negative Bacteria

by Vincent Lôme, Jean-Michel Brunel, Jean-Marie Pagès, Jean-Michel Bolla
Published 2018-02-01

Enantioselective HPLC Analysis to Assist the Chemical Exploration of Chiral Imidazolines

by Bruno Cerra, Antonio Macchiarulo, Andrea Carotti, Emidio Camaioni, Ina Varfaj, Roccaldo Sardella, Antimo Gioiello
Published 2020-02-01

Hits-to-Lead Optimization of the Natural Compound 2,4,6-Trihydroxy-3-geranyl-acetophenone (tHGA...

by Chean Hui Ng, Kamal Rullah, Faridah Abas, Kok Wai Lam, Intan Safinar Ismail, Fadzureena Jamaludin, Khozirah Shaari
Published 2018-09-01

Cheminformatic Profiling and Hit Prioritization of Natural Products with Activities against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA)

by Samson O. Oselusi, Samuel A. Egieyeh, Alan Christoffels
Published 2021-06-01

Conception, synthèse et développement de nouvelles molécules de type biguanide pour contourner la résistance aux médicaments dans le mélanome

by Grytsai, Oleksandr
Published 2018

Stratifying antimalarial compounds with similar mode of action using machine learning on chemo-transcriptomic profiles

by Van Heerden, Ashleigh
Published 2020