A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays

by Nicolas Creusot, Clémentine Garoche, Marina Grimaldi, Abdelhay Boulahtouf, Barbara Chiavarina, William Bourguet, Patrick Balaguer
Published 2021-05-01

Regulation of CAR and PXR Expression in Health and Disease

by Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin
Published 2020-10-01

Transcriptional Regulation of Pregnane X Receptor by Protein Arginine Methyltransferase

by Xie, Ying
Published 2011

Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

by Jiachao Guo, Weijin Li, Yingxing Wu, Xingzhi Jing, Junming Huang, Jiaming Zhang, Wei Xiang, Ranyue Ren, Zhengtao Lv, Jun Xiao, Fengjing Guo
Published 2017-10-01

Corrigendum: Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR

by Jiachao Guo, Weijin Li, Yingxing Wu, Xingzhi Jing, Junming Huang, Jiaming Zhang, Wei Xiang, Ranyue Ren, Zhengtao Lv, Jun Xiao, Fengjing Guo
Published 2018-01-01

Zearalenone-Induced Interaction between PXR and Sp1 Increases Binding of Sp1 to a Promoter Site of the eNOS, Decreasing Its Transcription and NO Production in BAECs

by Hyeon-Ju Lee, Jung-Hyun Park, Se-Young Oh, Du-Hyong Cho, Suji Kim, Inho Jo
Published 2020-06-01

Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment

by Aikaterini Skandalaki, Panagiotis Sarantis, Stamatios Theocharis
Published 2021-08-01

Germline Polymorphisms in the Nuclear Receptors PXR and VDR as Novel Prognostic Markers in Metastatic Colorectal Cancer Patients Treated With FOLFIRI

by Elena De Mattia, Jerry Polesel, Rossana Roncato, Adrien Labriet, Alessia Bignucolo, Eva Dreussi, Loredana Romanato, Michela Guardascione, Angela Buonadonna, Mario D'Andrea, Eric Lévesque, Derek Jonker, Félix Couture, Chantal Guillemette, Erika Cecchin, Giuseppe Toffoli
Published 2019-11-01

A Functional Polymorphism in the 3'-UTR of PXR Interacts with Smoking to Increase Lung Cancer Risk in Southern and Eastern Chinese Smoker

by Lisha Zhang, Fuman Qiu, Xiaoxiao Lu, Yinyan Li, Wenxiang Fang, Lan Zhang, Yifeng Zhou, Lei Yang, Jiachun Lu
Published 2014-09-01

The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

by Nicolas Creusot, Matthieu Gassiot, Elina Alaterre, Barbara Chiavarina, Marina Grimaldi, Abdelhay Boulahtouf, Lucia Toporova, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Alice Matheux, Roger Rahmani, Céline Gongora, Alexandre Evrard, Philippe Pourquier, Patrick Balaguer
Published 2020-07-01

Indolepropionic Acid, a Metabolite of the Microbiome, Has Cytostatic Properties in Breast Cancer by Activating AHR and PXR Receptors and Inducing Oxidative Stress

by Zsanett Sári, Edit Mikó, Tünde Kovács, Laura Jankó, Tamás Csonka, Gréta Lente, Éva Sebő, Judit Tóth, Dezső Tóth, Péter Árkosy, Anita Boratkó, Gyula Ujlaki, Miklós Török, Ilona Kovács, Judit Szabó, Borbála Kiss, Gábor Méhes, James J. Goedert, Péter Bai
Published 2020-08-01

Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications

by Jiezhong Chen, Luis Vitetta
Published 2020-07-01

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

by Amit V. Pandey, Amit V. Pandey, Colin J. Henderson, Yuji Ishii, Michel Kranendonk, Wayne L. Backes, Ulrich M. Zanger, Ulrich M. Zanger
Published 2017-11-01

Phallusiasterols A and B: Two New Sulfated Sterols from the Mediterranean Tunicate Phallusia fumigata and Their Effects as Modulators of the PXR Receptor

by Concetta Imperatore, Filomena D'Aniello, Anna Aiello, Stefano Fiorucci, Claudio D'Amore, Valentina Sepe, Marialuisa Menna
Published 2014-04-01

Novel Functions for the Pregnane X Receptor include Regulation of mRNA Turnover and Involvement in Colon Cancer Progression

by Eagleton, Navada Lorraine
Published 2011

Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR

by Na Yao, Caiwen Zeng, Tao Zhan, Fang He, Mingyi Liu, Fanglan Liu, Hong Zhang, Yuqing Xiong, Chunhua Xia
Published 2019-09-01

Phase-1 bioactivation mechanisms of aflatoxin through AhR, CAR and PXR nuclear receptors and the interactions with Nigella sativa seeds and thymoquinone in broilers

by Mehmet Burak Ates, Mustafa Ortatatli
Published 2021-01-01

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

by Swart Marelize, Whitehorn Heather, Ren Yuan, Smith Peter, Ramesar Rajkumar S, Dandara Collet
Published 2012-11-01

Effects of Vitamin K2 on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR

by Halima Sultana, Kimika Watanabe, Md Masud Rana, Rie Takashima, Ai Ohashi, Michio Komai, Hitoshi Shirakawa
Published 2018-07-01

Pregnane X receptor (PXR)-mediated gene repression and cross-talk of PXR with other nuclear receptors via coactivator interactions

by Petr Pavek
Published 2016-11-01