Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival

by Matilda Munksgaard Thorén, Katarzyna Chmielarska Masoumi, Cecilia Krona, Xiaoli Huang, Soumi Kundu, Linnéa Schmidt, Karin Forsberg-Nilsson, Marcus Floyd Keep, Elisabet Englund, Sven Nelander, Bo Holmqvist, Evy Lundgren-Åkerlund
Published 2019-04-01

Preclinical Activity of Sacituzumab Govitecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) Linked to the Active Metabolite of Irinotecan (SN-38...

by Emanuele Perrone, Emanuele Perrone, Salvatore Lopez, Salvatore Lopez, Burak Zeybek, Stefania Bellone, Elena Bonazzoli, Silvia Pelligra, Luca Zammataro, Aranzazu Manzano, Paola Manara, Anna Bianchi, Natalia Buza, Joan Tymon-Rosario, Gary Altwerger, Chanhee Han, Gulden Menderes, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Pei Hui, Peter E. Schwartz, Giovanni Scambia, Alessandro D. Santin
Published 2020-02-01

PDL-1 Antibody Drug Conjugate for Selective Chemo-Guided Immune Modulation of Cancer

by Samaresh Sau, Alex Petrovici, Hashem O. Alsaab, Ketki Bhise, Arun K. Iyer
Published 2019-02-01

Current LC-MS-based strategies for characterization and quantification of antibody-drug conjugates

by Xiaoyu Zhu, Shihan Huo, Chao Xue, Bo An, Jun Qu
Published 2020-06-01

Tumor Extrinsic Factors Mediate Primary T-DM1 Resistance in HER2-Positive Breast Cancer Cells

by Yukinori Endo, Wen Jin Wu
Published 2021-05-01

Therapeutic Application of Drug-Conjugated HER2 Oligobody (HER2-DOligobody)

by Hyun Jung Kim, Ho Jin Sung, Yul Min Lee, Sun Il Choi, Yun-Hee Kim, Kyun Heo, In-Hoo Kim
Published 2020-05-01

A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma

by Ricarda M. Hoffmann, Silvia Crescioli, Silvia Mele, Eirini Sachouli, Anthony Cheung, Connie K. Chui, Paolo Andriollo, Paul J. M. Jackson, Katie E. Lacy, James F. Spicer, David E. Thurston, Sophia N. Karagiannis
Published 2020-04-01

Use of a charge reducing agent to enable intact mass analysis of cysteine-linked antibody-drug-conjugates by native mass spectrometry

by Kamila J. Pacholarz, Perdita E. Barran
Published 2016-06-01

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

by Ricarda M. Hoffmann, Ben G. T. Coumbe, Debra H. Josephs, Silvia Mele, Kristina M. Ilieva, Anthony Cheung, Andrew N. Tutt, James F. Spicer, David E. Thurston, Silvia Crescioli, Sophia N. Karagiannis
Published 2018-03-01

Novel Antibody Drug Conjugates Targeting Tumor-Associated Receptor Tyrosine Kinase ROR2 by Functional Screening of Fully Human Antibody Libraries Using Transpo-mAb Display on Proge...

by Ina Hellmann, Lorenz Waldmeier, Marie-Christine Bannwarth-Escher, Kseniya Maslova, Fabian I. Wolter, Ulf Grawunder, Roger R. Beerli
Published 2018-11-01

Design and Validation of Linkers for Site-Specific Preparation of Antibody–Drug Conjugates Carrying Multiple Drug Copies per Cysteine Conjugation Site

by Amit Kumar, Shenlan Mao, Nazzareno Dimasi, Changshou Gao
Published 2020-09-01

Whole-Body Pharmacokinetics and Physiologically Based Pharmacokinetic Model for Monomethyl Auristatin E (MMAE)

by Hsuan Ping Chang, Yuen Kiu Cheung, Dhaval K. Shah
Published 2021-03-01

Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY^®) Antibody–Drug Conjugate in Sprague Dawley Rats

by Victor Yip, M. Violet Lee, Ola M. Saad, Shuguang Ma, S. Cyrus Khojasteh, Ben-Quan Shen
Published 2021-03-01

Predictable Peptide Conjugation Ratios by Activation of Proteins with Succinimidyl Iodoacetate (SIA)

by Ioana M. Abbas, Timm Schwaar, Frank Bienwald, Michael G. Weller
Published 2017-09-01

PEG Linker Improves Antitumor Efficacy and Safety of Affibody-Based Drug Conjugates

by Qiyu Li, Wenjing Li, Keyuan Xu, Yutong Xing, Haobo Shi, Zhe Jing, Shuang Li, Zhangyong Hong
Published 2021-02-01

State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis

by Evolène Deslignière, Anthony Ehkirch, Bastiaan L. Duivelshof, Hanna Toftevall, Jonathan Sjögren, Davy Guillarme, Valentina D’Atri, Alain Beck, Oscar Hernandez-Alba, Sarah Cianférani
Published 2021-05-01

In Vitro Cytotoxicity of Trastuzumab (Tz) and Se-Trastuzumab (Se-Tz) Against the Her/2 Breast Cancer Cell Lines JIMT-1 and BT-474

by Priyanka Bapat, Debalina Goswami Sewell, Mallory Boylan, Arun K. Sharma, Julian E. Spallholz
Published 2021-04-01

Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma

by Emily Capone, Alessia Lamolinara, Fabio Pastorino, Roberta Gentile, Sara Ponziani, Giulia Di Vittorio, Daniela D’Agostino, Sandra Bibbò, Cosmo Rossi, Enza Piccolo, Valentina Iacobelli, Rossano Lattanzio, Valeria Panella, Michele Sallese, Vincenzo De Laurenzi, Francesco Giansanti, Arturo Sala, Manuela Iezzi, Mirco Ponzoni, Rodolfo Ippoliti, Stefano Iacobelli, Gianluca Sala
Published 2020-10-01

Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates

by David J. Newman, Gordon M. Cragg
Published 2017-03-01

DLL3: an emerging target in small cell lung cancer

by Dwight H. Owen, Michael J. Giffin, Julie M. Bailis, Marie-Anne Damiette Smit, David P. Carbone, Kai He
Published 2019-06-01