The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains

by Alan Rodriguez Carvajal, Irina Grishkovskaya, Carlos Gomez Diaz, Antonia Vogel, Adar Sonn-Segev, Manish S Kushwah, Katrin Schodl, Luiza Deszcz, Zsuzsanna Orban-Nemeth, Shinji Sakamoto, Karl Mechtler, Philipp Kukura, Tim Clausen, David Haselbach, Fumiyo Ikeda
Published 2021-06-01

The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

by Katalin Skrapits, Miklós Sárvári, Imre Farkas, Balázs Göcz, Szabolcs Takács, Éva Rumpler, Viktória Váczi, Csaba Vastagh, Gergely Rácz, András Matolcsy, Norbert Solymosi, Szilárd Póliska, Blanka Tóth, Ferenc Erdélyi, Gábor Szabó, Michael D Culler, Cecile Allet, Ludovica Cotellessa, Vincent Prévot, Paolo Giacobini, Erik Hrabovszky
Published 2021-06-01

Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice

by Seungjin Ryu, Irina Shchukina, Yun-Hee Youm, Hua Qing, Brandon Hilliard, Tamara Dlugos, Xinbo Zhang, Yuki Yasumoto, Carmen J Booth, Carlos Fernández-Hernando, Yajaira Suárez, Kamal Khanna, Tamas L Horvath, Marcelo O Dietrich, Maxim Artyomov, Andrew Wang, Vishwa Deep Dixit
Published 2021-06-01

The human cerebellum is essential for modulating perceptual sensitivity based on temporal expectations

by Assaf Breska, Richard B Ivry
Published 2021-06-01

Nanoscape, a data-driven 3D real-time interactive virtual cell environment

by Shereen R Kadir, Andrew Lilja, Nick Gunn, Campbell Strong, Rowan T Hughes, Benjamin J Bailey, James Rae, Robert G Parton, John McGhee
Published 2021-06-01

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

by Yang Guo, Ze-Yan Yu, Jianxin Wu, Hutao Gong, Scott Kesteven, Siiri E Iismaa, Andrea Y Chan, Sara Holman, Silvia Pinto, Andy Pironet, Charles D Cox, Robert M Graham, Rudi Vennekens, Michael P Feneley, Boris Martinac
Published 2021-06-01

Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity

by Line S Löken, Joao M Braz, Alexander Etlin, Mahsa Sadeghi, Mollie Bernstein, Madison Jewell, Marilyn Steyert, Julia Kuhn, Katherine Hamel, Ida J Llewellyn-Smith, Allan Basbaum
Published 2021-06-01

Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

by Wenqing Li, Virginia Tran, Iftach Shaked, Belinda Xue, Thomas Moore, Rhonda Lightle, David Kleinfeld, Issam A Awad, Mark H Ginsberg
Published 2021-05-01

Watching hair turn grey

by Michael P Philpott
Published 2021-06-01

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

by Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero
Published 2021-06-01

SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B

by Wei Fan, Shuang Tang, Xiaojuan Fan, Yi Fang, Xiaojiang Xu, Leping Li, Jian Xu, Jian-Liang Li, Zefeng Wang, Xiaoling Li
Published 2021-05-01

Cortical signatures of precision grip force control in children, adolescents, and adults

by Mikkel Malling Beck, Meaghan Elizabeth Spedden, Martin Jensen Dietz, Anke Ninija Karabanov, Mark Schram Christensen, Jesper Lundbye-Jensen
Published 2021-06-01

Allosteric conformational ensembles have unlimited capacity for integrating information

by John W Biddle, Rosa Martinez-Corral, Felix Wong, Jeremy Gunawardena
Published 2021-06-01

Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta

by Matthew William Grol, Nele A Haelterman, Joohyun Lim, Elda M Munivez, Marilyn Archer, David M Hudson, Sara F Tufa, Douglas R Keene, Kevin Lei, Dongsu Park, Cole D Kuzawa, Catherine G Ambrose, David R Eyre, Brendan H Lee
Published 2021-05-01

Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway

by Shu-Min Chou, Ke-Xin Li, Ming-Yueh Huang, Chao Chen, Yuan-Hung Lin King, Grant Guangnan Li, Wei Zhou, Chin Fen Teo, Yuh Nung Jan, Lily Yeh Jan, Shi-Bing Yang
Published 2021-05-01

circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

by Minmin Song, Guangfeng Zhao, Haixiang Sun, Simin Yao, Zhenhua Zhou, Peipei Jiang, Qianwen Wu, Hui Zhu, Huiyan Wang, Chenyan Dai, Jingmei Wang, Ruotian Li, Yun Cao, Haining Lv, Dan Liu, Jianwu Dai, Yan Zhou, Yali Hu
Published 2021-06-01

The social life of cyanobacteria

by Conrad W Mullineaux, Annegret Wilde
Published 2021-06-01

Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

by Stephanie E Crilly, Wooree Ko, Zara Y Weinberg, Manojkumar A Puthenveedu
Published 2021-05-01

Understanding the evolution of multiple drug resistance in structured populations

by David V McLeod, Sylvain Gandon
Published 2021-06-01

Rigorous review and editorial oversight of clinical preprints

by Mone Zaidi, Diane M Harper, Anna Akhmanova, Detlef Weigel, Timothy E Behrens, Michael B Eisen
Published 2021-06-01