Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.

by P J Klasse, Thomas J Ketas, Christopher A Cottrell, Gabriel Ozorowski, Gargi Debnath, Diawoye Camara, Erik Francomano, Pavel Pugach, Rajesh P Ringe, Celia C LaBranche, Marit J van Gils, Christine A Bricault, Dan H Barouch, Shane Crotty, Guido Silvestri, Sudhir Kasturi, Bali Pulendran, Ian A Wilson, David C Montefiori, Rogier W Sanders, Andrew B Ward, John P Moore
Published 2018-02-01

Immunogenicity of a novel Clade B HIV-1 vaccine combination: Results of phase 1 randomized placebo controlled trial of an HIV-1 GM-CSF-expressing DNA prime with a modified vaccinia...

by Susan P Buchbinder, Nicole A Grunenberg, Brittany J Sanchez, Kelly E Seaton, Guido Ferrari, M Anthony Moody, Nicole Frahm, David C Montefiori, Christine M Hay, Paul A Goepfert, Lindsey R Baden, Harriet L Robinson, Xuesong Yu, Peter B Gilbert, M Juliana McElrath, Yunda Huang, Georgia D Tomaras, HIV Vaccine Trials Network (HVTN) 094 Study Group
Published 2017-01-01

Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

by David R. Martinez, Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, Juilin Chen, Michael Mengual, Ayooluwa O. Douglas, Holly Heimsath, Kevin O. Saunders, Nathan I. Nicely, Joshua Eudailey, Giovanna Hernandez, Papa Kwadwo Morgan-Asiedu, Kevin Wiehe, Barton F. Haynes, M. Anthony Moody, Celia LaBranche, David C. Montefiori, Feng Gao, Sallie R. Permar
Published 2020-03-01

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

by Kevin O. Saunders, Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, Maggie Barr, Amanda Eaton, Giovanna Hernandez, Derrick Goodman, Michael J. Hogan, Istvan Tombacz, David N. Gordon, R. Wes Rountree, Yunfei Wang, Mark G. Lewis, Theodore C. Pierson, Chris Barbosa, Ying Tam, Xiaoying Shen, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, Drew Weissman, Barton F. Haynes
Published 2021-04-01

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.

by Fangping Cai, Wei-Hung Chen, Weimin Wu, Julia A Jones, Misook Choe, Neelakshi Gohain, Xiaoying Shen, Celia LaBranche, Amanda Eaton, Laura Sutherland, Esther M Lee, Giovanna E Hernandez, Nelson R Wu, Richard Scearce, Michael S Seaman, M Anthony Moody, Sampa Santra, Kevin Wiehe, Georgia D Tomaras, Kshitij Wagh, Bette Korber, Mattia Bonsignori, David C Montefiori, Barton F Haynes, Natalia de Val, M Gordon Joyce, Kevin O Saunders
Published 2021-06-01

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

by Hongshuo Song, Elena E. Giorgi, Vitaly V. Ganusov, Fangping Cai, Gayathri Athreya, Hyejin Yoon, Oana Carja, Bhavna Hora, Peter Hraber, Ethan Romero-Severson, Chunlai Jiang, Xiaojun Li, Shuyi Wang, Hui Li, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Nilu Goonetilleke, Brandon F. Keele, David C. Montefiori, Myron S. Cohen, George M. Shaw, Beatrice H. Hahn, Andrew J. McMichael, Barton F. Haynes, Bette Korber, Tanmoy Bhattacharya, Feng Gao
Published 2018-05-01

Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women.

by Peter B Gilbert, Jean-Louis Excler, Georgia D Tomaras, Lindsay N Carpp, Barton F Haynes, Hua-Xin Liao, David C Montefiori, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Jaranit Kaewkungwal, Gustavo H Kijak, Sodsai Tovanabutra, Donald P Francis, Carter Lee, Faruk Sinangil, Phillip W Berman, Nakorn Premsri, Prayura Kunasol, Robert J O'Connell, Nelson L Michael, Merlin L Robb, Rhoda Morrow, Lawrence Corey, Jerome H Kim
Published 2017-01-01

Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adult...

by Kenneth H Mayer, Kelly E Seaton, Yunda Huang, Nicole Grunenberg, Abby Isaacs, Mary Allen, Julie E Ledgerwood, Ian Frank, Magdalena E Sobieszczyk, Lindsey R Baden, Benigno Rodriguez, Hong Van Tieu, Georgia D Tomaras, Aaron Deal, Derrick Goodman, Robert T Bailer, Guido Ferrari, Ryan Jensen, John Hural, Barney S Graham, John R Mascola, Lawrence Corey, David C Montefiori, HVTN 104 Protocol Team, and the NIAID HIV Vaccine Trials Network
Published 2017-11-01

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting.

by Nicole A Doria-Rose, Han R Altae-Tran, Ryan S Roark, Stephen D Schmidt, Matthew S Sutton, Mark K Louder, Gwo-Yu Chuang, Robert T Bailer, Valerie Cortez, Rui Kong, Krisha McKee, Sijy O'Dell, Felicia Wang, Salim S Abdool Karim, James M Binley, Mark Connors, Barton F Haynes, Malcolm A Martin, David C Montefiori, Lynn Morris, Julie Overbaugh, Peter D Kwong, John R Mascola, Ivelin S Georgiev
Published 2017-01-01

Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals.

by Davide Corti, Johannes P M Langedijk, Andreas Hinz, Michael S Seaman, Fabrizia Vanzetta, Blanca M Fernandez-Rodriguez, Chiara Silacci, Debora Pinna, David Jarrossay, Sunita Balla-Jhagjhoorsingh, Betty Willems, Maria J Zekveld, Hanna Dreja, Eithne O'Sullivan, Corinna Pade, Chloe Orkin, Simon A Jeffs, David C Montefiori, David Davis, Winfried Weissenhorn, Aine McKnight, Jonathan L Heeney, Federica Sallusto, Quentin J Sattentau, Robin A Weiss, Antonio Lanzavecchia
Published 2010-01-01

Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site

by Todd Bradley, Daniela Fera, Jinal Bhiman, Leila Eslamizar, Xiaozhi Lu, Kara Anasti, Ruijung Zhang, Laura L. Sutherland, Richard M. Scearce, Cindy M. Bowman, Christina Stolarchuk, Krissey E. Lloyd, Robert Parks, Amanda Eaton, Andrew Foulger, Xiaoyan Nie, Salim S. Abdool Karim, Susan Barnett, Garnett Kelsoe, Thomas B. Kepler, S. Munir Alam, David C. Montefiori, M. Anthony Moody, Hua-Xin Liao, Lynn Morris, Sampa Santra, Stephen C. Harrison, Barton F. Haynes
Published 2016-01-01

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.

by Ema T Crooks, Tommy Tong, Bimal Chakrabarti, Kristin Narayan, Ivelin S Georgiev, Sergey Menis, Xiaoxing Huang, Daniel Kulp, Keiko Osawa, Janelle Muranaka, Guillaume Stewart-Jones, Joanne Destefano, Sijy O'Dell, Celia LaBranche, James E Robinson, David C Montefiori, Krisha McKee, Sean X Du, Nicole Doria-Rose, Peter D Kwong, John R Mascola, Ping Zhu, William R Schief, Richard T Wyatt, Robert G Whalen, James M Binley
Published 2015-05-01

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.

by Celia C LaBranche, Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, Kevin O Saunders, S Munir Alam, Mattia Bonsignori, Mario J Borgnia, Quentin J Sattentau, Amanda Eaton, Kelli Greene, Hongmei Gao, Hua-Xin Liao, Wilton B Williams, James Peacock, Haili Tang, Lautaro G Perez, Robert J Edwards, Thomas B Kepler, Bette T Korber, Peter D Kwong, John R Mascola, Priyamvada Acharya, Barton F Haynes, David C Montefiori
Published 2019-09-01

ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type.

by Luca Schifanella, Susan W Barnett, Massimiliano Bissa, Veronica Galli, Melvin N Doster, Monica Vaccari, Georgia D Tomaras, Xiaoying Shen, Sanjay Phogat, Ranajit Pal, David C Montefiori, Celia C LaBranche, Mangala Rao, Hung V Trinh, Robyn Washington-Parks, Namal P M Liyanage, Giacomo Gorini, Dallas R Brown, Frank Liang, Karin Loré, David J Venzon, William Magnanelli, Michelle Metrinko, Josh Kramer, Matthew Breed, Galit Alter, Ruth M Ruprecht, Genoveffa Franchini
Published 2019-12-01

Correction: ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type.

by Luca Schifanella, Susan W Barnett, Massimiliano Bissa, Veronica Galli, Melvin N Doster, Monica Vaccari, Georgia D Tomaras, Xiaoying Shen, Sanjay Phogat, Ranajit Pal, David C Montefiori, Celia C LaBranche, Mangala Rao, Hung V Trinh, Robyn Washington-Parks, Namal P M Liyanage, Giacomo Gorini, Dallas R Brown, Frank Liang, Karin Loré, David J Venzon, William Magnanelli, Michelle Metrinko, Josh Kramer, Matthew Breed, Galit Alter, Ruth M Ruprecht, Genoveffa Franchini
Published 2020-04-01

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.

by Celia C LaBranche, Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, Kevin O Saunders, S Munir Alam, Mattia Bonsignori, Mario J Borgnia, Quentin J Sattentau, Amanda Eaton, Kelli Greene, Hongmei Gao, Hua-Xin Liao, Wilton B Williams, James Peacock, Haili Tang, Lautaro G Perez, Robert J Edwards, Thomas B Kepler, Bette T Korber, Peter D Kwong, John R Mascola, Priyamvada Acharya, Barton F Haynes, David C Montefiori
Published 2019-12-01

Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization

by Qifeng Han, Todd Bradley, Wilton B. Williams, Derek W. Cain, David C. Montefiori, Kevin O. Saunders, Robert J. Parks, Regina W. Edwards, Guido Ferrari, Olaf Mueller, Xiaoying Shen, Kevin J. Wiehe, Steven Reed, Christopher B. Fox, Wes Rountree, Nathan A. Vandergrift, Yunfei Wang, Laura L. Sutherland, Sampa Santra, M. Anthony Moody, Sallie R. Permar, Georgia D. Tomaras, Mark G. Lewis, Koen K.A. Van Rompay, Barton F. Haynes
Published 2020-02-01

Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques.

by Gerard Zurawski, Sandra Zurawski, Anne-Laure Flamar, Laura Richert, Ralf Wagner, Georgia D Tomaras, David C Montefiori, Mario Roederer, Guido Ferrari, Christine Lacabaratz, Henri Bonnabau, Peter Klucar, Zhiqing Wang, Kathryn E Foulds, Shing-Fen Kao, Nicole L Yates, Celia LaBranche, Bertram L Jacobs, Karen Kibler, Benedikt Asbach, Alexander Kliche, Andres Salazar, Steve Reed, Steve Self, Raphael Gottardo, Lindsey Galmin, Deborah Weiss, Anthony Cristillo, Rodolphe Thiebaut, Giuseppe Pantaleo, Yves Levy
Published 2016-01-01

A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204).

by Gavin J Churchyard, Cecilia Morgan, Elizabeth Adams, John Hural, Barney S Graham, Zoe Moodie, Doug Grove, Glenda Gray, Linda-Gail Bekker, M Juliana McElrath, Georgia D Tomaras, Paul Goepfert, Spyros Kalams, Lindsey R Baden, Michelle Lally, Raphael Dolin, William Blattner, Artur Kalichman, J Peter Figueroa, Jean Pape, Mauro Schechter, Olivier Defawe, Stephen C De Rosa, David C Montefiori, Gary J Nabel, Lawrence Corey, Michael C Keefer, NIAID HIV Vaccine Trials Network
Published 2011-01-01

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape.

by Katharine J Bar, Chun-yen Tsao, Shilpa S Iyer, Julie M Decker, Yongping Yang, Mattia Bonsignori, Xi Chen, Kwan-Ki Hwang, David C Montefiori, Hua-Xin Liao, Peter Hraber, William Fischer, Hui Li, Shuyi Wang, Sarah Sterrett, Brandon F Keele, Vitaly V Ganusov, Alan S Perelson, Bette T Korber, Ivelin Georgiev, Jason S McLellan, Jeffrey W Pavlicek, Feng Gao, Barton F Haynes, Beatrice H Hahn, Peter D Kwong, George M Shaw
Published 2012-01-01