MYCN is an immunosuppressive oncogene dampening the expression of ligands for NK-cell-activating receptors in human high-risk neuroblastoma

by Elisa Brandetti, Irene Veneziani, Ombretta Melaiu, Annalisa Pezzolo, Aurora Castellano, Renata Boldrini, Elisa Ferretti, Doriana Fruci, Lorenzo Moretta, Vito Pistoia, Franco Locatelli, Loredana Cifaldi
Published 2017-06-01

EZH2 Down-Regulation Exacerbates Lipid Accumulation and Inflammation in in Vitro and in Vivo NAFLD

by Serena Vella, Daniela Gnani, Annalisa Crudele, Sara Ceccarelli, Cristiano De Stefanis, Stefania Gaspari, Valerio Nobili, Franco Locatelli, Victor E Marquez, Rossella Rota, Anna Alisi
Published 2013-12-01

Author Correction: Blinatumomab in pediatric patients with relapsed/refractory acute lymphoblastic leukemia: results of the RIALTO trial, an expanded access study

by Franco Locatelli, Gerhard Zugmaier, Noemi Mergen, Peter Bader, Sima Jeha, Paul-Gerhardt Schlegel, Jean-Pierre Bourquin, Rupert Handgretinger, Benoit Brethon, Claudia Rossig, Christiane Chen-Santel
Published 2021-02-01

Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome Children

by Chiara Lanzillotta, Viviana Greco, Diletta Valentini, Alberto Villani, Valentina Folgiero, Matteo Caforio, Franco Locatelli, Sara Pagnotta, Eugenio Barone, Andrea Urbani, Fabio Di Domenico, Marzia Perluigi
Published 2020-11-01

Inhibition of Methyltransferase DOT1L Sensitizes to Sorafenib Treatment AML Cells Irrespective of <i>MLL</i>-Rearrangements: A Novel Therapeutic Strategy for Pediatric AML

by Annalisa Lonetti, Valentina Indio, Maria Antonella Laginestra, Giuseppe Tarantino, Francesca Chiarini, Annalisa Astolfi, Salvatore N. Bertuccio, Alberto M. Martelli, Franco Locatelli, Andrea Pession, Riccardo Masetti
Published 2020-07-01

NPM1 Mutational Status Underlines Different Biological Features in Pediatric AML

by Claudia Tregnago, Maddalena Benetton, Davide Padrin, Katia Polato, Giulia Borella, Ambra Da Ros, Anna Marchetti, Elena Porcù, Francesca Del Bufalo, Cristina Mecucci, Franco Locatelli, Martina Pigazzi
Published 2021-07-01

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing

by Tiziano Ingegnere, Francesca Romana Mariotti, Andrea Pelosi, Concetta Quintarelli, Concetta Quintarelli, Biagio De Angelis, Nicola Tumino, Francesca Besi, Claudia Cantoni, Franco Locatelli, Paola Vacca, Lorenzo Moretta
Published 2019-04-01

High-resolution array CGH profiling identifies Na/K transporting ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in neuroblastoma.

by Paolo Romania, Aurora Castellano, Cecilia Surace, Arianna Citti, Maria Antonietta De Ioris, Pietro Sirleto, Marilena De Mariano, Luca Longo, Renata Boldrini, Adriano Angioni, Franco Locatelli, Doriana Fruci
Published 2013-01-01

β-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest

by Agnese Po, Federica Begalli, Luana Abballe, Vincenzo Alfano, Zein Mersini Besharat, Giuseppina Catanzaro, Alessandra Vacca, Maddalena Napolitano, Marco Tafani, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti, Evelina Miele
Published 2017-01-01

T‐cell depleted HLA‐haploidentical HSCT in a child with neuromyelitis optica

by Giulia Ceglie, Laura Papetti, Lorenzo Figà Talamanca, Barbarella Lucarelli, Mattia Algeri, Stefania Gaspari, Giuseppina Li Pira, Giovanna‐Stefania Colafati, Mauro Montanari, Massimiliano Valeriani, Franco Locatelli, Pietro Merli
Published 2019-10-01

Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2–host interactome

by Francesco Messina, Emanuela Giombini, Chiara Montaldo, Ashish Arunkumar Sharma, Antonio Zoccoli, Rafick-Pierre Sekaly, Franco Locatelli, Alimuddin Zumla, Markus Maeurer, Maria R. Capobianchi, Francesco Nicola Lauria, Giuseppe Ippolito
Published 2021-08-01

Reversible induction of mitophagy by an optogenetic bimodular system

by Pasquale D’Acunzo, Flavie Strappazzon, Ignazio Caruana, Giacomo Meneghetti, Anthea Di Rita, Luca Simula, Gerrit Weber, Francesca Del Bufalo, Luisa Dalla Valle, Silvia Campello, Franco Locatelli, Francesco Cecconi
Published 2019-04-01

Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma

by Ombretta Melaiu, Marco Chierici, Valeria Lucarini, Giuseppe Jurman, Libenzio Adrian Conti, Rita De Vito, Renata Boldrini, Loredana Cifaldi, Aurora Castellano, Cesare Furlanello, Vincenzo Barnaba, Franco Locatelli, Doriana Fruci
Published 2020-11-01

Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model

by Paola Bocca, Emma Di Carlo, Ignazio Caruana, Laura Emionite, Michele Cilli, Biagio De Angelis, Concetta Quintarelli, Annalisa Pezzolo, Lizzia Raffaghello, Fabio Morandi, Franco Locatelli, Vito Pistoia, Ignazia Prigione
Published 2018-01-01

IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma.

by Silvia Lorenzi, Matteo Forloni, Loredana Cifaldi, Chiara Antonucci, Arianna Citti, Renata Boldrini, Marco Pezzullo, Aurora Castellano, Vincenzo Russo, Pierre van der Bruggen, Patrizio Giacomini, Franco Locatelli, Doriana Fruci
Published 2012-01-01

Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway

by Annalisa Lonetti, Alessandra Cappellini, Alice Bertaina, Franco Locatelli, Andrea Pession, Francesca Buontempo, Camilla Evangelisti, Cecilia Evangelisti, Ester Orsini, Laura Zambonin, Luca Maria Neri, Alberto Maria Martelli, Francesca Chiarini
Published 2016-10-01

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs

by Giuseppina Catanzaro, Zein Mersini Besharat, Neha Garg, Maurizio Ronci, Luisa Pieroni, Evelina Miele, Angela Mastronuzzi, Andrea Carai, Vincenzo Alfano, Agnese Po, Isabella Screpanti, Franco Locatelli, Andrea Urbani, Elisabetta Ferretti
Published 2016-01-01

Ewing sarcoma of the bone in children under 6 years of age.

by Maria Antonietta De Ioris, Arcangelo Prete, Raffaele Cozza, Marta Podda, Carla Manzitti, Andrea Pession, Elisabetta Schiavello, Benedetta Contoli, Rita Balter, Franca Fagioli, Gianni Bisogno, Loredana Amoroso, Franco Locatelli, Roberto Luksch
Published 2013-01-01

The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties.

by Francesca Rossi, Maria Ester Bernardo, Giulia Bellini, Livio Luongo, Antonella Conforti, Iolanda Manzo, Francesca Guida, Luigia Cristino, Roberta Imperatore, Stefania Petrosino, Bruno Nobili, Vincenzo Di Marzo, Franco Locatelli, Sabatino Maione
Published 2013-01-01

ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism

by Valentina Tassinari, Valeriana Cesarini, Sara Tomaselli, Zaira Ianniello, Domenico Alessandro Silvestris, Lavinia Ceci Ginistrelli, Maurizio Martini, Biagio De Angelis, Gabriele De Luca, Lucia Ricci Vitiani, Alessandro Fatica, Franco Locatelli, Angela Gallo
Published 2021-01-01