From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc

by Chirag Dhar, Chirag Dhar, Aniruddha Sasmal, Aniruddha Sasmal, Ajit Varki, Ajit Varki
Published 2019-04-01

Ongoing selection for a uniquely human null allele of SIGLEC12 in world‐wide populations may protect against the risk of advanced carcinomas

by Shoib S. Siddiqui, Michael Vaill, Ajit Varki
Published 2021-04-01

Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain

by Vinay S. Mahajan, Ezana Demissie, Hamid Mattoo, Vinay Viswanadham, Ajit Varki, Robert Morris, Shiv Pillai
Published 2016-05-01

A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease.

by Vered Padler-Karavani, Adriana H Tremoulet, Hai Yu, Xi Chen, Jane C Burns, Ajit Varki
Published 2013-01-01

Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo.

by Yung-Chi Chang, Joshua Olson, Federico C Beasley, Christine Tung, Jiquan Zhang, Paul R Crocker, Ajit Varki, Victor Nizet
Published 2014-01-01

N-glycolyl chondroitin synthesis using metabolically engineered E. coli

by Adeola E. Awofiranye, Sultan N. Baytas, Ke Xia, Abinaya Badri, Wenqin He, Ajit Varki, Mattheos Koffas, Robert J. Linhardt
Published 2020-08-01

Correction: An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.

by Hao Song, Jianxun Qi, Zahra Khedri, Sandra Diaz, Hai Yu, Xi Chen, Ajit Varki, Yi Shi, George F Gao
Published 2016-03-01

An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.

by Hao Song, Jianxun Qi, Zahra Khedri, Sandra Diaz, Hai Yu, Xi Chen, Ajit Varki, Yi Shi, George F Gao
Published 2016-01-01

A comparative study of N-glycolylneuraminic acid (Neu5Gc) and cytotoxic T cell (CT) carbohydrate expression in normal and dystrophin-deficient dog and human skeletal muscle.

by Paul T Martin, Bethannie Golden, Jonathan Okerblom, Marybeth Camboni, Kumaran Chandrasekharan, Rui Xu, Ajit Varki, Kevin M Flanigan, Joe N Kornegay
Published 2014-01-01

Oral streptococci utilize a Siglec-like domain of serine-rich repeat adhesins to preferentially target platelet sialoglycans in human blood.

by Lingquan Deng, Barbara A Bensing, Supaporn Thamadilok, Hai Yu, Kam Lau, Xi Chen, Stefan Ruhl, Paul M Sullam, Ajit Varki
Published 2014-12-01

Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages

by Chih-Ming Tsai, Angelica M. Riestra, Syed Raza Ali, Jerry J. Fong, Janet Z. Liu, Gillian Hughes, Ajit Varki, Victor Nizet
Published 2019-12-01

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates

by Toshiyuki Hayakawa, Zahra Khedri, Flavio Schwarz, Corinna Landig, Suh-Yuen Liang, Hai Yu, Xi Chen, Naoko T. Fujito, Yoko Satta, Ajit Varki, Takashi Angata
Published 2017-11-01

Evolution of the exclusively human pathogen Neisseria gonorrhoeae: Human‐specific engagement of immunoregulatory Siglecs

by Corinna S. Landig, Ashley Hazel, Benjamin P. Kellman, Jerry J. Fong, Flavio Schwarz, Sarika Agarwal, Nissi Varki, Paola Massari, Nathan E. Lewis, Sanjay Ram, Ajit Varki
Published 2019-02-01

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

by Sandra L Diaz, Vered Padler-Karavani, Darius Ghaderi, Nancy Hurtado-Ziola, Hai Yu, Xi Chen, Els C M Brinkman-Van der Linden, Ajit Varki, Nissi M Varki
Published 2009-01-01

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera.

by Frederico Alisson-Silva, Janet Z Liu, Sandra L Diaz, Lingquan Deng, Mélanie G Gareau, Ronald Marchelletta, Xi Chen, Victor Nizet, Nissi Varki, Kim E Barrett, Ajit Varki
Published 2018-06-01

Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus

by Brian R. Wasik, Karen N. Barnard, Robert J. Ossiboff, Zahra Khedri, Kurtis H. Feng, Hai Yu, Xi Chen, Daniel R. Perez, Ajit Varki, Colin R. Parrish, W. Paul Duprex
Published 2017-09-01

Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G.

by Shohei Ogata, Chisato Shimizu, Alessandra Franco, Ranim Touma, John T Kanegaye, Biswa P Choudhury, Natasha N Naidu, Yutaka Kanda, Long T Hoang, Martin L Hibberd, Adriana H Tremoulet, Ajit Varki, Jane C Burns
Published 2013-01-01

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation

by Preston S. K. Ng, Christopher J. Day, John M. Atack, Lauren E. Hartley-Tassell, Linda E. Winter, Tal Marshanski, Vered Padler-Karavani, Ajit Varki, Stephen J. Barenkamp, Michael A. Apicella, Michael P. Jennings
Published 2019-05-01

Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression

by Shoib S Siddiqui, Michael Vaill, Raymond Do, Naazneen Khan, Andrea L Verhagen, Wu Zhang, Heinz‐Josef Lenz, Teresa L Johnson‐Pais, Robin J Leach, Gary Fraser, Charles Wang, Gen‐Sheng Feng, Nissi Varki, Ajit Varki
Published 2021-02-01

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals:...

by Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki
Published 2018-01-01