Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation

by Melissa Conti Mazza, Alexandra Beilina, Dorien A. Roosen, David Hauser, Mark R. Cookson
Published 2021-08-01

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.

by Azad Kumar, Elisa Greggio, Alexandra Beilina, Alice Kaganovich, Diane Chan, Jean-Marc Taymans, Benjamin Wolozin, Mark R Cookson
Published 2010-01-01

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.

by Jean-Marc Taymans, Renée Vancraenenbroeck, Petri Ollikainen, Alexandra Beilina, Evy Lobbestael, Marc De Maeyer, Veerle Baekelandt, Mark R Cookson
Published 2011-01-01

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

by George R. Heaton, Natalie Landeck, Adamantios Mamais, Mike A. Nalls, Jonathon Nixon-Abell, Ravindran Kumaran, Alexandra Beilina, Laura Pellegrini, Yan Li, Kirsten Harvey, Mark R. Cookson
Published 2020-07-01

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.

by Laura Civiero, Renée Vancraenenbroeck, Elisa Belluzzi, Alexandra Beilina, Evy Lobbestael, Lauran Reyniers, Fangye Gao, Ivan Micetic, Marc De Maeyer, Luigi Bubacco, Veerle Baekelandt, Mark R Cookson, Elisa Greggio, Jean-Marc Taymans
Published 2012-01-01

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

by Anna Sandebring, Kelly Jean Thomas, Alexandra Beilina, Marcel van der Brug, Megan M Cleland, Rili Ahmad, David W Miller, Ibardo Zambrano, Richard F Cowburn, Homira Behbahani, Angel Cedazo-Mínguez, Mark R Cookson
Published 2009-05-01

The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

by Alexandra Beilina, Luis Bonet-Ponce, Ravindran Kumaran, Jennifer J. Kordich, Morié Ishida, Adamantios Mamais, Alice Kaganovich, Sara Saez-Atienzar, David C. Gershlick, Dorien A. Roosen, Laura Pellegrini, Vlad Malkov, Matthew J. Fell, Kirsten Harvey, Juan S. Bonifacino, Darren J. Moore, Mark R. Cookson
Published 2020-05-01

Hexokinases link DJ-1 to the PINK1/parkin pathway

by David N. Hauser, Adamantios Mamais, Melissa M. Conti, Christopher T. Primiani, Ravindran Kumaran, Allissa A. Dillman, Rebekah G. Langston, Alexandra Beilina, Joseph H. Garcia, Alberto Diaz-Ruiz, Michel Bernier, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo, Mark R. Cookson
Published 2017-09-01

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

by Elisa Greggio, Shushant Jain, Ann Kingsbury, Rina Bandopadhyay, Patrick Lewis, Alice Kaganovich, Marcel P. van der Brug, Alexandra Beilina, Jeff Blackinton, Kelly Jean Thomas, Rili Ahmad, David W. Miller, Sashi Kesavapany, Andrew Singleton, Andrew Lees, Robert J. Harvey, Kirsten Harvey, Mark R. Cookson
Published 2006-08-01